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NHP-immunome: A translational research-oriented database of non-human primate immune system proteins

机译：NHP-IMMUNME：一个翻译的非人灵长类动物免疫系统蛋白的导向性数据库

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摘要

We are currently living the advent of a new age for medicine in which basic research is being quickly translated into marketable drugs, and the widespread access to genomics data is allowing the design and implementation of personalized solutions to medical conditions. Non-human primates (NHP) have gained an essential role in drug discovery and safety testing due to their close phylogenetic relationship to humans. In this study, a collection of well characterized genes of the human immune system was used to define the orthology-based immunome in four NHP species, with carefully curated annotations available based on multi-tissue RNA-seq datasets. A broad variation in the frequency of expressed protein isoforms was observed between species. Finally, this analysis also revealed the lack of expression of at least four different chemokines in new-world primates. In addition, transcripts corresponding to four genes including interleukin 12 subunit alpha were expressed in humans but no other primate species analyzed. Access to the non-human primate immunome is available in http://www.fidic.org.co:90/proyecto/.
机译：我们目前正在居住在新时代的药物中的出现，其中基本研究正在迅速转化为可销售药物，并且对基因组学数据的广泛访问允许设计和实施用于医疗条件的个性化解决方案。由于它们与人类密切的系统发育关系密切相关，非人的灵长类动物（NHP）在药物发现和安全测试中获得了重要作用。在该研究中，使用了人类免疫系统的良好表征基因的集合，用于在四种NHP物种中定义基于正非的免疫蛋白，具有基于多组织RNA-SEQ数据集可用的精心策划注释。在物种之间观察到表达蛋白质同种型的频率的广泛变化。最后，该分析还揭示了在新世界的灵长类动物中缺乏至少四种不同的趋化因子的表达。此外，对应于四种基因的转录物，包括白细胞介素12亚基α在人类中表达，但没有分析其他灵长类动物的物种。在http://www.fidic.org.co:90/proyecto/中提供对非人类灵长类会主体免疫疫苗。

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