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首页> 外文期刊>Cellular immunology >Exploring new immunological insight on SP15 (～14?kDa) family protein in saliva of Indian sand-fly ( Phlebotomus argentipes ) in experimental visceral leishmaniasis
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Exploring new immunological insight on SP15 (～14?kDa) family protein in saliva of Indian sand-fly ( Phlebotomus argentipes ) in experimental visceral leishmaniasis

机译：在实验性内脏LeishManiaisis中探索SP15（〜14 kda）家族蛋白的新免疫洞察SP15（〜14 kda）家族蛋白质

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摘要

Visceral leishmaniasis (VL) is a disease caused by protozoan species of the genusLeishmaniaand is transmitted through bites from thePhlebotomussand fly; it is associated with considerable morbidity and mortality in many parts of world, including India. Reports on the protective role played by saliva proteins ofLutozomyia longipalpis, Phlebotomus papatasi and Phlebotomus duboscqi. are available. However, no studies have explored the salivary proteins ofP.argentipes, which is the known proven vector for the transmission of VL in the Indian sub-continent. Herein we revealed the presence of two proteins of 14.2 and one protein of 13.6?kDa in Indian strainP. argentipeswhich is absolute identical to previously reported protein of SP15 family (PagSP01, PagSP02 and PagSP07) ofP. argentipesof NIH colony, USA. In an experimental study onP. argentipesfrom Bihar, India, we demonstrated that a strong humoral and cellular immune response was triggered to reduce the concomitantLeishmaniaload in groups of immunized mice. The immunized group produced a considerable amount of IgG antibodies, and their splenocytes generated TH1 cytokines (IL-12, IFN-γ) with the support of delayed-type hypersensitivity (DTH) reactivity in such mice at the challenged site. We summarize from our data that some identical proteins to previous from SP15 family protein of 14.2 and 13.6?kDa molecular size, derived from IndianP. argentipesand reported its first time, can also be significant in resolution of VL infection after modulation of host protective T cell response in VL.
机译：内脏Leishmaniaisis（VL）是由遗传物种的原生动物种类引起的疾病，通过Thephlebotomussand飞过咬伤;在包括印度的世界许多地区，它与世界上许多地区有相当大的发病率和死亡率有关。关于唾液蛋白唾液蛋白，Hongipalpis，Phlebotomus Papatasi和Hlebotomus duboshqi的保护作用的报告。可用。然而，没有研究已经探索了P.Argeripes的唾液蛋白，这是印度亚大陆在印度副大陆传播的已知经过证明的载体。在此，我们揭示了两个14.2蛋白的存在14.2蛋白和13.6克的蛋白质在印度菌株。 Argentipesswhi ich绝对与先前报告的SP15家族（PAGSP01，PAGSP02和PAGSP07）的蛋白质相同。 NIH殖民地，美国阿根廷艾率。在一个实验研究ONP。 ArgentipesFharfrom Bihar，India，我们证明触发了强烈的体液和细胞免疫应答，以减少免疫小鼠组中的ConcoInantLyhismoad。免疫基团产生了相当大量的IgG抗体，它们的脾细胞产生TH1细胞因子（IL-12，IFN-γ），在攻击部位的延迟型超敏反应（DTH）反应性的支持下。我们从我们的数据总结了一些相同的蛋白质到先前来自SP15家族蛋白的14.2和13.6？KDA分子大小，来自印第安普。阿根廷人和第一次报道，在vl中的宿主保护T细胞反应后，在调制宿主保护T细胞响应后，也可能是显着的。

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  • 来源
    《Cellular immunology》 |2018年第2018期|共7页
  • 作者

    Pushpanjali; Ghufran Ahmed; Ajit K. Thakur; Snehil; Fauzia Jamal; Manish K. Singh; Ajay Kumar; Subhankar K. Singh; Sanjiva Bimal; Pradeep Das; Shyam Narayan;

  • 作者单位

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research) Agam;

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research) Agam;

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research) Agam;

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research) Agam;

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research) Agam;

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research) Agam;

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research) Agam;

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research) Agam;

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research) Agam;

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research) Agam;

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research) Agam;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Phlebotomus argentipes; Visceral leishmaniasis; Salivary gland homogenate; SP15 family proteins; Anti-saliva antibodies; Cytokines;

    机译：Phlebotomus argentipes;内脏Leishmaniaisis;唾液腺匀浆;SP15家族蛋白;抗唾液抗体;细胞因子;

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