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Recent advances into the role of pattern recognition receptors in transplantation

机译：最近进入模式识别受体在移植中的作用

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Pattern recognition receptors (PRRs) are germline-encoded sensors best characterized for their critical role in host defense. However, there is accumulating evidence that organ transplantation induces the release or display of molecular patterns of cellular injury and death that trigger PRR-mediated inflammatory responses. There are also new insights that indicate PRRs are able to distinguish between self and non-self, suggesting the existence of non-clonal mechanisms of allorecognition. Collectively, these reports have spurred considerable interest into whether PRRs or their ligands can be targeted to promote transplant survival. This review examines the mounting evidence that PRRs play in transplant-mediated inflammation. Given the large number of PRRs, we will focus on members from four families: the complement system, toll-like receptors, the formylated peptide receptor, and scavenger receptors through examining reports of their activity in experimental models of cellular and solid organ transplantation as well as in the clinical setting.
机译：模式识别受体（PRRS）是种子编码的传感器，最能表征其在主防御中的关键作用。然而，积累了器官移植的证据诱导触发PRR介导的炎症反应的细胞损伤和死亡的分子模式的释放或显示。还有新的见解表明PRRS能够区分自我和非自我，这表明存在的非克隆机制的不克隆机制。总的来说，这些报告对PRR或其配体是否可以促进移植生存期来激发了相当大的兴趣。该审查审查了PRRS在移植介导的炎症中发挥的安装证据。鉴于大量的PRR，我们将专注于四个家庭的成员：补体系统，含量的肽受体，甲型肽受体和清除剂受体，通过检查其在细胞和固体器官移植的实验模型中的活性报告如在临床环境中。

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