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首页> 外文期刊>Cellular immunology >Burn injury is associated with an infiltration of the wound site with myeloid-derived suppressor cells
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Burn injury is associated with an infiltration of the wound site with myeloid-derived suppressor cells

机译：燃烧损伤与髓样衍生抑制细胞造成伤口部位的浸润有关

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摘要

Myeloid-derived suppressor cells (MDSCs) have been identified in the burn wound, however their characterization is incomplete. To study this, mice were subjected to a major burn and skin cells were isolated 3 days thereafter for analysis. Significant infiltration of the burn wound with MDSCs was observed as compared with uninjured skin. The skin of naive mice did not contain MDSCs. Characterization of the cells showed that 33% of MDSCs in the wound were monocytic (M)-MDSCs, which was significantly less than that found in uninjured skin (52%). In contrast, polymorphonuclear (PMN)-MDSCs were greater in the burn wound as compared with uninjured skin. Burn wound TLR expression by both MDSCs subsets was decreased as compared with uninjured skin. Wound MDSCs produced pro- and anti-inflammatory cytokines and iNOS was present in both MDSC subsets, whereas ARG1 was only present in M-MDSCs. In conclusion, both M- and PMN-MDSCs infiltrate burn wound with after injury, however, they displayed decreased TLR expression, suggesting receptor down-regulation.
机译：已经在烧伤伤口中鉴定了髓样衍生的抑制细胞（MDSC），但其表征是不完整的。为了研究这一点，将小鼠进行大规模的烧伤，然后将皮肤细胞分离3天进行分析。与未加注的皮肤相比，观察到用MDSCs的烧伤伤口的显着渗透。幼稚小鼠的皮肤不含MDSC。细胞的表征表明，伤口中33％的MDSC是单核细胞（M）-MDSCs，其明显小于未加注的皮肤（52％）。相比之下，与未受约束的皮肤相比，多晶核（PMN）-MDSC在燃烧伤口中更大。与未受约束的皮肤相比，MDSCS子集的烧伤伤口TLR表达减少。伤口MDSCS产生的抗炎细胞因子和InOS存在于两个MDSC子集中，而Arg1仅存在于MSCS中。总之，M-和PMN-MDSCS浸润损伤损伤后损伤，然而，它们表现出降低的TLR表达，表明受体下调。

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