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首页> 外文期刊>Cell cycle >A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer
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A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer

机译：非小细胞肺癌肿瘤进展中促进复合亚基10的新型功能

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摘要

The anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase, is responsible for the transition from metaphase to anaphase and the exit from mitosis. The anaphase promoting complex subunit 10 (APC10), a subunit of the APC/C, executes a vital function in substrate recognition. However, no research has reported the connection between APC10 and cancer until now. In this study, we uncovered a novel, unprecedented role of APC10 in tumor progression, which is independent of APC/C. First, aberrant increase of APC10 expression was validated in non-small cell lung cancer (NSCLC) cells and tissues, and the absence of APC10 repressed cell proliferation and migration. Of great interest, we found that APC10 inhibition induced cell cycle arrest at the G0/G1 phase and reduced the expression of the APC/C substrate, Cyclin B1; this finding is different from the conventional concept of the accumulation of Cyclin B1 and cell cycle arrest in metaphase. Further, APC10 was found to interact with glutaminase C (GAC), and the inhibition of APC10 weakened glutamine metabolism and induced excessive autophagy. Taken together, these findings identify a novel function of APC10 in the regulation of NSCLC tumorigenesis and point to the possibility of APC10 as a new target for cancer therapy.
机译：促进复合物/环体（APC / C）的后期调节的E3泛素连接酶，负责从中期转变到后期和从有丝分裂的出口。促进复合亚基10（APC10）的APC / C的亚基在基板识别中执行重要函数。然而，没有研究报告APC10和癌症之间的联系，直到现在。在这项研究中，我们发现了一种新颖的，前所未有的APC10在肿瘤进展中的作用，其与APC / C无关。首先，在非小细胞肺癌（NSCLC）细胞和组织中验证了APC10表达的异常增加，并且没有APC10压抑细胞增殖和迁移。大量兴趣，我们发现APC10抑制诱导在G0 / G1相处的细胞周期停滞，并降低了APC / C底物的表达，细胞周期蛋白B1;该发现与细胞周期蛋白B1和中期细胞周期停滞的常规概念不同。此外，发现APC10与谷氨酰胺酶C（GAC）相互作用，并且APC10的抑制弱化谷氨酰胺代谢和诱导过量的自噬。总之，这些发现鉴定了APC10的新功能在NSCLC肿瘤肿瘤的调节中，并指向APC10作为癌症治疗的新靶标的可能性。

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  • 来源
    《Cell cycle》 |2019年第9期|共14页
  • 作者

    Wang Yanan; Han Tianyu; Gan Mingxi; Guo Meng; Xie Caifeng; Jin Jiangbo; Zhang Song; Wang Pengcheng; Cao Jiaqing; Wang Jian-Bin;

  • 作者单位

    Nanchang Univ Sch Life Sci Nanchang Jiangxi Peoples R China;

    Nanchang Univ Affiliated Hosp 1 Dept Respirat Nanchang Jiangxi Peoples R China;

    Nanchang Univ Sch Basic Med Sci Nanchang Jiangxi Peoples R China;

    Nanchang Univ Sch Basic Med Sci Nanchang Jiangxi Peoples R China;

    Nanchang Univ Sch Basic Med Sci Nanchang Jiangxi Peoples R China;

    Nanchang Univ Sch Life Sci Nanchang Jiangxi Peoples R China;

    Nanchang Univ Sch Life Sci Nanchang Jiangxi Peoples R China;

    Nanchang Univ Sch Life Sci Nanchang Jiangxi Peoples R China;

    Nanchang Univ Affiliated Hosp 2 Dept Gastrointestinal Surg Nanchang Jiangxi Peoples R China;

    Nanchang Univ Sch Basic Med Sci Nanchang Jiangxi Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    APC10; GAC; glutamine metabolism; autophagy; NSCLC;

    机译：APC10;GAC;谷氨酰胺新陈代谢;自噬;NSCLC;

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