Pathways of oncogene-induced senescence in human melanocytic cells.

Bansal R; Nikiforov MA

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Pathways of oncogene-induced senescence in human melanocytic cells.

机译：癌基因族诱导的人黑脲细胞中衰老的途径。

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Senescence is a form of irreversible arrest of cell proliferation. In normal human cells it can occur either due to telomere abrasion that takes place after a certain number of cell divisions (replica-tive senescence) or due to the aberrant activation of oncogenes (oncogene-induced senescence [OIS]). Despite its generalized name, the bulk of available literature on OIS considers only two families of oncogenes: RAS2 and RAF. In normal rodent cultured cells and in the majority of mouse models, senescence phe-notypes caused by constitutively active RAF or RAS proteins are executed by pl9~(ARF)-p53 or pl6~(INK4A)-pRb pathways (reviewed in ref. 4), however, involvement of these pathways in OIS of human cells appears to be less straightforward.

机译：衰老是一种不可逆转的细胞增殖的形式。在正常的人体细胞中，它可能发生由于在一定数量的细胞分裂（复制品衰老）或由于癌基因的异常激活（癌基因诱导的衰老[OIS]）之后发生。尽管其广泛名称，OIS的大部分可用文献仅考虑了两个癌症的两个家庭：RAS2和RAF。在正常的啮齿动物培养细胞和大多数小鼠模型中，由组成型活性RAF或RAS蛋白引起的衰老PHE-缺口由PL9〜（ARF）-P53或PL6〜（INK4A）-PRB途径（在REF中审阅4 然而，然而，这些途径在人体细胞的OIS中的参与似乎不太直接。

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《Cell cycle》 |2010年第14期|共7页
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Bansal R; Nikiforov MA;
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Department of Cell Stress Biology Roswell Park Cancer Institute Buffalo NY USA.;

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正文语种 eng
中图分类细胞生物学;
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1. Pathways of oncogene-induced senescence in human melanocytic cells. [J] . Bansal R, Nikiforov MA Cell cycle . 2010,第14期

机译：癌基因族诱导的人黑脲细胞中衰老的途径。
2. The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells. [J] . Prigione A, Fauler B, Lurz R, Stem Cells . 2010,第4期

机译：在人类诱导的多能干细胞中，与衰老相关的线粒体/氧化应激途径受到抑制。
3. p34SEI-1 inhibits doxorubicin-induced senescence through a pathway mediated by protein kinase C-delta and c-Jun-NH2-kinase 1 activation in human breast cancer MCF7 cells. [J] . Lee SL, Hong SW, Shin JS, Molecular cancer research: MCR . 2009,第11期

机译：p34SEI-1在人乳腺癌MCF7细胞中通过蛋白激酶C-δ和c-Jun-NH2-激酶1激活介导的途径抑制阿霉素诱导的衰老。
4. Senescence of the human cone photoreceptor pathways [C] . Holger Knau, John S. Werner Topical Meeting on Vision Science and its Applications, Feb 11-14, 2000, Santa Fe, New Mexico . 2000

机译：人锥光感受器途径的衰老
5. Characterization of the relationship between the IGF-1R tyrosine kinase pathway and the notch signaling pathway with Human Aspartyl (Asparaginyl) beta-hydroxylase (HAAH) in lung cancer cells. [D] . Ranji, Cyra M. 2010

机译：肺癌细胞中IGF-1R酪氨酸激酶途径和Notch信号通路与人天冬氨酰（天冬酰胺基）β-羟化酶（HAAH）之间关系的表征。
6. Pathways of oncogene-induced senescence in human melanocytic cells [O] . Rajat Bansal, Mikhail A Nikiforov 2010

机译：致癌基因诱导人类黑素细胞衰老的途径
7. Pathways of oncogene-induced senescence in human melanocytic cells [O] . Bansal, Rajat, Nikiforov, Mikhail A 2010

机译：致癌基因诱导人类黑素细胞衰老的途径

Pathways of oncogene-induced senescence in human melanocytic cells.

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