• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytoskeleton >Moonlighting microtubule-associated proteins: Regulatory functions by day and pathological functions at night
【24h】

Moonlighting microtubule-associated proteins: Regulatory functions by day and pathological functions at night

机译：微管相关蛋白的月光照亮：白天的调节功能和晚上的病理功能

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The sensing, integrating, and coordinating features of the eukaryotic cells are achieved by the complex ultrastructural arrays and multifarious functions of the cytoskeletal network. Cytoskeleton comprises fibrous protein networks of microtubules, actin, and intermediate filaments. These filamentous polymer structures are highly dynamic and undergo constant and rapid reorganization during cellular processes. The microtubular system plays a crucial role in the brain, as it is involved in an enormous number of cellular events including cell differentiation and pathological inclusion formation. These multifarious functions of microtubules can be achieved by their decoration with proteins/enzymes that exert specific effects on the dynamics and organization of the cytoskeleton and mediate distinct functions due to their moonlighting features. This mini-review focuses on two aspects of the microtubule cytoskeleton. On the one hand, we describe the heteroassociation of tubulin/microtubules with metabolic enzymes, which in addition to their catalytic activities stabilize microtubule structures via their cross-linking functions. On the other hand, we focus on the recently identified moonlighting tubulin polymerization promoting protein, TPPP/p25. TPPP/p25 is a microtubule-associated protein and it displays distinct physiological or pathological (aberrant) functions; thus it is a prototype of Neomorphic Moonlighting Proteins. The expression of TPPP/p25 is finely controlled in the human brain; this protein is indispensable for the development of projections of oligodendrocytes that are responsible for the ensheathment of axons. The nonphysiological, higher or lower TPPP/p25 level leads to distinct CNS diseases. Mechanisms contributing to the control of microtubule stability and dynamics by metabolic enzymes and TPPP/p25 will be discussed.
机译：真核细胞的感测，整合和协调功能是通过复杂的超微结构阵列和细胞骨架网络的多种功能实现的。细胞骨架包含微管，肌动蛋白和中间丝的纤维蛋白网络。这些丝状聚合物结构是高度动态的，并且在细胞过程中经历恒定且快速的重组。微管系统在大脑中起着至关重要的作用，因为它参与了许多细胞事件，包括细胞分化和病理性包涵体形成。微管的这些多种功能可以通过用蛋白/酶修饰来实现，这些蛋白/酶对细胞骨架的动力学和组织起特定作用，并由于其月光照射特性而介导不同的功能。这项小型审查集中在微管细胞骨架的两个方面。一方面，我们描述了微管蛋白/微管与代谢酶的异缔合，其除了具有催化活性外，还通过其交联功能稳定了微管结构。另一方面，我们专注于最近发现的月光微管蛋白聚合促进蛋白TPPP / p25。 TPPP / p25是一种与微管相关的蛋白，具有独特的生理或病理（异常）功能。因此，它是新形态月光照蛋白的原型。在人脑中，TPPP / p25的表达受到良好控制。该蛋白对于少突胶质细胞投射的形成是必不可少的，而少突胶质细胞则负责轴突的包裹。非生理性的较高或较低的TPPP / p25水平会导致明显的中枢神经系统疾病。将讨论有助于通过代谢酶和TPPP / p25控制微管稳定性和动力学的机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号