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首页> 外文期刊>Cell cycle >Dietary quercetin ameliorates experimental colitis in mouse by remodeling the function of colonic macrophages via a heme oxygenase-1-dependent pathway
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Dietary quercetin ameliorates experimental colitis in mouse by remodeling the function of colonic macrophages via a heme oxygenase-1-dependent pathway

机译：通过通过血红素氧酶-1依赖性通路重塑结肠巨噬细胞的功能，饮食槲皮素在小鼠中改善实验性结肠炎

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摘要

Inflammatory bowel disease (IBD) results from a chronic intestinal inflammation and tissue destruction via an aberrant immune-driven inflammatory response towards an altered gut microbiota. Dietary intervention is becoming an attractive avenue for the therapy of colitis because diet is a key determinant of the mucosal immune response. Quercetin (QCN) is the most common in nature and the major representative of dietary antioxidant flavonoids, which has been demonstrated to influence the progression of colitis. However, the underlying mechanism of QCN on intestinal immunomodulation remains unclear. Here, our study demonstrated dietary QCN could ameliorate experimental colitis in part by modulating the anti-inflammatory effects and bactericidal capacity of macrophages via Heme oxygenase-1 (Hmox1, HO-1) dependent pathway. It suggested that QCN might restore the proper intestinal host-microbe relationship to ameliorate the colitis via rebalancing the pro-inflammatory, anti-inflammatory and bactericidal function of enteric macrophages. Hence, modulating the function of intestinal macrophages with dietary administration of QCN to restore the immunological hemostasis and rebalance the enteric commensal flora is a potential and promising strategy for IBD therapy.
机译：炎症性肠病（IBD）由慢性肠炎症和组织破坏通过异常免疫驱动的炎症反应而导致改变的肠道微生物肿瘤。饮食干预正在成为结肠炎治疗的有吸引力的途径，因为饮食是粘膜免疫应答的关键决定因素。槲皮素（QCN）是最常见的性质和主要代表膳食抗氧化类黄酮类化合物，这已经证明了影响结肠炎的进展。然而，QCN对肠免疫调节的潜在机制仍然尚不清楚。在这里，我们的研究证明了膳食QCN可以通过调节血红素氧酶-1（HMOX1，HO-1）依赖性途径的抗炎作用和杀菌能力来改善实验性结肠炎。它表明，QCN可能会恢复适当的肠道宿主微生物关系，以通过重新平衡肠溶巨噬细胞的促炎，抗炎和杀菌功能来改善结肠炎。因此，调节肠道巨噬细胞的饮食给药急诊急性血液溶解和重新平衡的肠道共生菌群是IBD治疗的潜在和有希望的策略。

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  • 来源
    《Cell cycle》 |2018年第1期|共11页
  • 作者

    Ju Songwen; Ge Yan; Li Ping; Tian Xinxin; Wang Haiyan; Zheng Xiaocui; Ju Songguang;

  • 作者单位

    Nanjing Med Univ Suzhou Municipal Hosp Cent Lab Affiliated Suzhou Hosp Suzhou Jiangsu Peoples;

    Soochow Univ Sch Biol &

    Basic Med Sci Dept Immunol Coll Med Suzhou 215123 Jiangsu Peoples R;

    Nanjing Med Univ Suzhou Municipal Hosp Suzhou Digest Dis &

    Nutr Res Ctr Affiliated Suzhou Hosp;

    Nanjing Municipal Govt Hosp Nanjing Jiangsu Peoples R China;

    Soochow Univ Sch Biol &

    Basic Med Sci Dept Immunol Coll Med Suzhou 215123 Jiangsu Peoples R;

    Soochow Univ Sch Biol &

    Basic Med Sci Dept Immunol Coll Med Suzhou 215123 Jiangsu Peoples R;

    Soochow Univ Sch Biol &

    Basic Med Sci Dept Immunol Coll Med Suzhou 215123 Jiangsu Peoples R;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Inflammatory bowel disease; colitis; Quercetin; macrophage; immunological hemostasis; enteric commensal flora; HO-1;

    机译：炎症性肠病;结肠炎;槲皮素;巨噬细胞;免疫止血;肠溶类别植物;HO-1;

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