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首页> 外文期刊>Cell cycle >CircPCNXL2 sponges miR-153 to promote the proliferation and invasion of renal cancer cells through upregulating ZEB2
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CircPCNXL2 sponges miR-153 to promote the proliferation and invasion of renal cancer cells through upregulating ZEB2

机译：CircPCNXL2海绵MiR-153通过上调Zeb2促进肾癌细胞的增殖和侵袭

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摘要

Increasing evidence showed that circular RNAs (circRNAs) play critical roles in tumorigenesis. However, the roles and underlying mechanisms of circRNAs in clear cell renal cell carcinoma (ccRCC) remain unclear. In the present study, we identified a novel circRNA circPCNXL2, which was significantly upregulated in ccRCC by circular RNA microarray. Further analysis revealed that circPCNXL2 was significantly increased and correlated with poor overall survival of ccRCC patients. Function assays revealed that circPCNXL2 knockdown reduced RCC cells proliferation, invasion in vitro, and decreased tumor growth in vivo. In mechanism study, we showed that circPCNXL2 could be bind to miR-153 as a miRNA sponge to regulate ZEB2 expression in RCC progression. In addition, our data reported that the effects of circPCNXL2 inhibition on RCC cells proliferation and invasion could be abolished by miR-153 inhibitors. Altogether, we demonstrated that circPCNXL2 could regulate RCC cells proliferation and invasion by miR-153/ZEB2 axis, suggesting circPCNXL2 might serve as a potential therapeutic target for ccRCC treatment.
机译：越来越多的证据表明，圆形RNA（CircRNA）在肿瘤发生中发挥着关键作用。然而，Circrnas在透明细胞肾细胞癌（CCRCC）中的作用和潜在机制仍然尚不清楚。在本研究中，我们鉴定了一种新的CircrNA CircPCNXL2，通过圆形RNA微阵列在CCRCC中显着上调。进一步的分析显示，CCRCC患者的整体存活率显着增加，循环循环显着增加和相关。功能测定揭示了CircpCnXL2敲低降低RCC细胞增殖，体外侵袭，体内肿瘤生长降低。在机制研究中，我们表明昼麻可以与miR-153结合，作为miRNA海绵，以调节RCC进展中的Zeb2表达。此外，我们的数据报告说，MiR-153抑制剂可以废除CirPCNXL2抑制对RCC细胞增殖和侵袭的影响。总之，我们证明了MiR-153 / Zeb2轴的rCCNXL2可以调节RCC细胞增殖和侵袭，旨在作为CCRCC治疗的潜在治疗靶标。

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