Targeting Chk1 in the replicative stress response.

Grant S

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Targeting Chk1 in the replicative stress response.

机译：针对复制应力响应中的CHK1。

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In response to DNA damage or interference with DNA synthesis, transformed cells characteristically activate various checkpoints, which together comprise an important component of a complex signaling network that has been termed the DNA damage response (DDR). Checkpoints identified so far are classified in two ways: (1) cell cycle checkpoints: the G_1/S, intra-S or S, and G_2/M checkpoint; or (2) function-specific checkpoints: the DNA damage checkpoint, the replication checkpoint, the mitotic spindle checkpoint, the cytokinesis checkpoint, etc. The observation that transformed cells are characterized by defects in the checkpoint apparatus has prompted intense efforts to exploit this differential response (relative to normal cells) therapeutically.

机译：响应于DNA损伤或干扰DNA合成的干扰，转化的细胞特征性地激活各种检查点，其共同包括已被称为DNA损伤响应（DDR）的复杂信号通信网络的重要组成部分。到目前为止识别的检查站是以两种方式分类：（1）单元格循环检查点：G_1 / s，intra-s或s，g_2 / m检查点; 或（2）特定功能检查点：DNA损伤检查点，复制检查点，有丝分裂主轴检查点，细胞因子检查点等。转化的细胞的观察表征在检查点装置中的缺陷的特征在于，促使激烈的努力利用这种差异治疗上的反应（相对于正常细胞）。

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《Cell cycle》 |2010年第6期|共1页
作者
Grant S;
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作者单位

Department of Medicine and the Massey Cancer Center Virginia Commonwealth University Richmond VA USA.;

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正文语种 eng
中图分类细胞生物学;
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1. Targeting Chk1 in the replicative stress response. [J] . Grant S Cell cycle . 2010,第6期

机译：在复制应激反应中针对Chk1。
2. Targeting Chk1 in the replicative stress response. [J] . Grant S Cell cycle . 2010,第6期

机译：针对复制应力响应中的CHK1。
3. Targeting replication stress response using polypurine reverse hoogsteen hairpins directed against WEE1 and CHK1 genes in human cancer cells [J] . Biochemical Pharmacology . 2020,第期

机译：使用多腔逆向Hoogsteen发夹的靶向复制应力响应，针对人癌细胞中的WEE1和CHK1基因
4. System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modifier Target Proteins and Acceptor Lysines Relevant for Genome Stability [C] . Zhenyu Xiao, Jer-Gung Chang, Ivo A. Hendriks, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：响应于复制应力的Sumoylation Dynamics的系统范围分析揭示了新的小泛素样改性剂靶蛋白和受体赖氨酸，与基因组稳定性相关
5. Replication protein A and the DNA-dependent protein kinase: Targets and regulators of the DNA damage response. [D] . Block, Wesley D. 2005

机译：复制蛋白A和DNA依赖性蛋白激酶：DNA损伤反应的靶标和调节剂。
6. Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression [O] . Martina Proctor, Jazmina L. Gonzalez Cruz, Sheena M. Daignault-Mill, 2021

机译：使用CHK1抑制剂靶向复制应力促进生先生和NKT细胞免疫应答和肿瘤回归
7. Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing [O] . Feijoo C., Hall-Jackson C., Wu R., 2001

机译：DNa复制停滞期间哺乳动物Chk1的激活：Chk1在s期检查点监测复制起点的作用

Targeting Chk1 in the replicative stress response.

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