p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN.

Anderson DH

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p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN.

机译：P85通过P110（PI3K）和PTEN的双调节来控制通过PI3K / PTEN信号轴的通量在控制通量方面发挥着关键作用。

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The phosphatidylinositol 3-kinase (PI3K) pathway regulates cell growth, survival and proliferation in response to many stimuli and is frequently overactive in cancer cells.' The p1110 catalytic subunit of PI3K is a lipid kinase that generates phosphatidylinositol 3,4,5-trisphosphate (PI3,4,5P_3), a product dephosphorylated by PTEN. The PI3K product PI3,4,5P_3 is a key second messenger that relocalizes and induces the activation of PDK1 and Akt, important signaling kinases with many downstream targets involved in mediating cellular responses.

机译：磷脂酰肌醇3-激酶（PI3K）途径调节细胞生长，响应许多刺激的细胞生长，存活率和增殖，并且在癌细胞中经常过度活跃。 PI3K的P1110催化亚基是一种脂质激酶，其产生磷脂酰肌醇3,4,5-三磷酸（PI3,4,5p_3），通过PTEN去磷酸化的产物。 PI3K产品PI3,4,5P_3是重读和诱导PDK1和AKT的激活，重要的信号传导激酶，其中介导细胞反应的许多下游靶标的关键的第二信使。

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《Cell cycle》 |2010年第11期|共2页
作者
Anderson DH;
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Cancer Research Unit Saskatchewan Cancer Agency Saskatoon SK Canada.;

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正文语种 eng
中图分类细胞生物学;
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1. p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN. [J] . Anderson DH Cell cycle . 2010,第11期

机译：p85在通过p110（PI3K）和PTEN的双重调节来控制通过PI3K / PTEN信号轴的通量中起关键作用。
2. p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN. [J] . Anderson DH Cell cycle . 2010,第11期

机译：P85通过P110（PI3K）和PTEN的双调节来控制通过PI3K / PTEN信号轴的通量在控制通量方面发挥着关键作用。
3. p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN. [J] . Anderson DH Cell cycle . 2010,第11期

机译：P85通过P110（PI3K）和PTEN的双调节来控制通过PI3K / PTEN信号轴的通量在控制通量方面发挥着关键作用。
4. The Role of the PI3K Pathway in Anti-IgM (Anti-i) - ensitive and -Resistant B-cell Lymphomas Failure to Disengage PI3K Pathway Signaling Confers i-fi Resistance on the CH12 B Cell Lymphoma [C] . Gregory B. Carey, Laura Tonnetti, David W. Scott International Symposium on Programmed Cell Death . 2003

机译：PI3K途径在抗IgM（抗IgM（抗-Ig）的作用 - 最终和 - 抗生素B细胞淋巴瘤未脱离PI3K途径信号传导对CH12 B细胞淋巴瘤的I-FI阻力
5. The Role of miR-29 in Regulating the PTEN/PI3K Axis in B Lymphocytes [D] . Hines, Marcus . 2020

机译：miR-29在对B淋巴细胞中调节PTEN / PI3K轴的作用
6. Regulation of PI3K signaling in T cell acute lymphoblastic leukemia:a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role forPIK3CD [O] . Tian Yuan, Yaling Yang, Jiayu Chen, -1

机译：PI3K信号在T细胞急性淋巴细胞白血病中的调节：一种新颖的PTEN / Ikaros / miR-26b机制揭示了关键的靶向作用PIK3CD
7. Regulation of PI3K signaling in T-cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD [O] . T Yuan, Y Yang, J Chen, 2017

机译：T细胞急性淋巴细胞白血病中PI3K信号传导的调节：一种新型PTEN / IKAROS / MIR-26B机制，揭示了PIK3CD的关键可占状作用

p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN.

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