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The current view for the silencing of the spindle assembly checkpoint

机译：主轴组件检查点沉默的当前视图

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摘要

Chromosome bipolar attachment is achieved when sister kinetochores are attached by microtubules emanating from opposite spindle poles, and this process is essential for faithful chromosome segregation during anaphase. A fundamental question in cell biology is how cells ensure that chromosome segregation only occurs after bipolar attachment. It is well documented that unattached kinetochores activate the spindle assembly checkpoint (SAC) to delay chromosome segregation. Therefore, the silencing of the SAC is thought to trigger anaphase onset, but how correct chromosome attachment is coupled with SAC silencing and the subsequent anaphase onset is poorly understood. The establishment of chromosome bipolar attachment not only results in the occupancy of kinetochores by microtubules but also applies tension on sister kinetochores. A long-standing debate is whether the kinetochore attachment (occupancy) or the tension silences the SAC. Recent work in budding yeast reveals the SAC silencing network SSN that prevents SAC silencing prior to tension generation at kinetochores. Therefore, this signaling pathway ensures that SAC silencing and the subsequent anaphase onset occur only after chromosome bipolar attachment applies tension on chromosomes. This review will summarize the recent advances in the understanding of the SAC silencing process.
机译：当患有来自相反主轴杆的微管轴附着的微管术时，实现了染色体双极附着，并且该过程对于在后期的忠实染色体隔离是必不可少的。细胞生物学中的一个基本问题是细胞如何确保双极附着后仅发生染色体隔离。有很好的记录，未连接的Kinetochores激活主轴组件检查点（SAC）以延迟染色体隔离。因此，囊的沉默被认为是触发染色的发作，但是如何正确染色体附着与囊沉默，随后的后期发作较差地理解。染色体双极附着的建立不仅导致Microtubes的Kinetochores的占用，而且还在姐妹Kinetochores施加张力。长期辩论是kinetochore附件（占用）或张力沉默囊。崭露头角酵母的最新工作揭示了囊沉默网络SSN，可防止在Kinetochores张力发电之前防止囊沉默。因此，该信号传导途径确保仅在染色体双极附件施加染色体上施加张力之后发生囊沉默和随后的后源性发作。本次审查将总结最近对囊沉默过程的理解进步。

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  • 来源
    《Cell cycle》 |2014年第11期|共8页
  • 作者

    WangY.; JinF.; HigginsR.; McKnightK.;

  • 作者单位

    Department of Biomedical Sciences College of Medicine Florida State University Tallahassee FL;

    Department of Biomedical Sciences College of Medicine Florida State University Tallahassee FL;

    Department of Biomedical Sciences College of Medicine Florida State University Tallahassee FL;

    Department of Biomedical Sciences College of Medicine Florida State University Tallahassee FL;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Checkpoint control; Chromosomes; Mitosis; Yeast biology;

    机译：检查点控制;染色体;有丝分裂;酵母生物学;

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