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The current view for the silencing of the spindle assembly checkpoint

机译：消隐主轴组件检查点的当前视图

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Chromosome bipolar attachment is achieved when sister kinetochores are attached by microtubules emanating from opposite spindle poles, and this process is essential for faithful chromosome segregation during anaphase. A fundamental question in cell biology is how cells ensure that chromosome segregation only occurs after bipolar attachment. It is well documented that unattached kinetochores activate the spindle assembly checkpoint (SAC) to delay chromosome segregation. Therefore, the silencing of the SAC is thought to trigger anaphase onset, but how correct chromosome attachment is coupled with SAC silencing and the subsequent anaphase onset is poorly understood. The establishment of chromosome bipolar attachment not only results in the occupancy of kinetochores by microtubules but also applies tension on sister kinetochores. A long-standing debate is whether the kinetochore attachment (occupancy) or the tension silences the SAC. Recent work in budding yeast reveals the SAC silencing network SSN that prevents SAC silencing prior to tension generation at kinetochores. Therefore, this signaling pathway ensures that SAC silencing and the subsequent anaphase onset occur only after chromosome bipolar attachment applies tension on chromosomes. This review will summarize the recent advances in the understanding of the SAC silencing process.
机译：当姐妹动植物通过相反的纺锤极发出的微管附着时，即可实现染色体双极附着，而此过程对于后期阶段忠实的染色体分离至关重要。细胞生物学中的一个基本问题是细胞如何确保染色体分离仅在双极附着后发生。众所周知，独立的动植物可以激活纺锤体装配检查点（SAC）以延迟染色体分离。因此，人们认为SAC沉默会触发后期发作，但对正确的染色体附着与SAC沉默如何耦合以及随后的后期发作知之甚少。染色体双极性附着的建立不仅导致微管占据动植物，而且在姐妹动植物上施加张力。长期存在的争论是，动线体的附着（占用）或张力是否会使SAC沉默。酵母发芽的最新研究揭示了SAC沉默网络SSN，可防止在动植物产生张力之前SAC沉默。因此，该信号传导途径确保仅在染色体双极附着对染色体施加张力后才发生SAC沉默和随后的后期发作。本文将总结在了解SAC沉默过程方面的最新进展。

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