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The role of Dickkopf-1 as a potential prognostic marker in pancreatic ductal adenocarcinoma

机译：Dickkopf-1作为胰腺导管腺癌中的潜在预后标志物的作用

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摘要

Dickkopf-1(DKK-1), the downstream target of beta-catenin/T-cell factor, participates in a negative feedback loop in the Wnt signaling and reported as an important biomarker in many tumors. In this study, we analyzed the expression of DKK-1 in pancreatic ductal adenocarcinoma (PDAC) patients at both mRNA and protein levels. We used real-time PCR to detect the expression of DKK-1 in 32 PDAC and paired adjacent non-tumor tissues, results suggested that the expression of DKK-1 was increased in PDAC tissues. We found the similar results in the analysis of 3 independent microarray data sets. Immunohistochemical staining of 311 pairs of PDAC tissues suggested that DKK-1 expression was significantly associated with T classification (P = 0.039) and lymph node metastasis (P = 0.035). Furthermore, Kaplan-Meier analysis for DKK-1 expression demonstrated that patients with higher DKK-1 level had shorter overall survival (OS) and relapse-free survival (RFS) time in Ren Ji cohort and online PDAC database at both mRNA and protein levels. Univariable and multivariable Cox regression analysis confirmed that DKK-1 as well as lymph node metastasis and histology were independent predictors of OS in patients with PDAC. This study demonstrated that DKK-1 may be a predictor for prognosis in PDAC patients.
机译：Dickkopf-1（DKK-1），β-连环蛋白/ T细胞因子的下游靶，参与WNT信号传导中的负反馈环，并作为许多肿瘤中的重要生物标志物报告。在这项研究中，我们分析了在mRNA和蛋白质水平的胰腺导管腺癌（PDAC）患者中DKK-1的表达。我们使用实时PCR检测32pdAc中DKK-1的表达，并配对相邻的非肿瘤组织，结果表明DKK-1的表达在PDAC组织中增加。我们发现了类似的结果在分析3个独立的微阵列数据集中。 311对PDAC组织的免疫组织化学染色表明DKK-1表达与T分类显着相关（P = 0.039）和淋巴结转移（P = 0.035）。此外，DKK-1表达的Kaplan-Meier分析表明，DKK-1水平较高的患者在MRNA和蛋白质水平的任人队队列和在线PDAC数据库中的整体存活（OS）和无复发存活（RFS）时间较短。不可变性和多变量的Cox回归分析证实，DKK-1以及淋巴结转移和组织学是PDAC患者患者OS的独立预测因子。该研究表明，DKK-1可以是PDAC患者预后的预测因子。

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  • 来源
    《Cell cycle》 |2017年第17期|共8页
  • 作者

    Liu De-Jun; Xie Yue-Xia; Liu Xiao-Xing; Huo Yan-Miao; Yang Min-Wei; Fu Xue-Liang; Liu Wei; Yang Jian-Yu; Li Jiao; Hua Rong; Liu Pei-Feng; Sun Yong-Wei; Zhang Jun-Feng;

  • 作者单位

    Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Biliary Pancreat Surg Dept 1630 Dongfang Rd;

    Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Cent Lab Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Dept Radiat Oncol Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Biliary Pancreat Surg Dept 1630 Dongfang Rd;

    Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Biliary Pancreat Surg Dept 1630 Dongfang Rd;

    Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Biliary Pancreat Surg Dept 1630 Dongfang Rd;

    Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Biliary Pancreat Surg Dept 1630 Dongfang Rd;

    Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Biliary Pancreat Surg Dept 1630 Dongfang Rd;

    Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Biliary Pancreat Surg Dept 1630 Dongfang Rd;

    Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Biliary Pancreat Surg Dept 1630 Dongfang Rd;

    Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Cent Lab Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Biliary Pancreat Surg Dept 1630 Dongfang Rd;

    Shanghai Jiao Tong Univ Sch Med Ren Ji Hosp Biliary Pancreat Surg Dept 1630 Dongfang Rd;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    DKK-1; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Tissue microarray; Prognosis; Biomarker; Wnt signaling;

    机译：DKK-1;胰腺癌;胰腺导管腺癌;组织微阵列;预后;生物标志物;WNT信号传导;

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