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首页> 外文期刊>Cell cycle >Tex10 is upregulated and promotes cancer stem cell properties and chemoresistance in hepatocellular carcinoma
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Tex10 is upregulated and promotes cancer stem cell properties and chemoresistance in hepatocellular carcinoma

机译：Tex10上调并促进癌细胞癌中的癌症干细胞性能和化学抑制剂

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摘要

Testis expressed 10 (Tex10), a new core component of the pluripotency circuitry, has been reported to positively regulate embryonic stem cell (ESC) super-enhancers to promote ESC self-renewal; however, the expression and function of Tex10 in hepatocellular carcinoma (HCC) and liver cancer stem cells remains unclear. The present study was designed to investigate the expression patterns of Tex10 with immunohistochemistry, western blotting and RT-qPCR in samples from HCC patients and HCC cell lines. The results obtained show that Tex10 was highly expressed in HCC tissues, and elevated Tex10 protein levels positively correlate with the poorly differentiated carcinoma. Likewise, we found that Tex10 expression in the high-metastasis HCCLM3 potential cell line was higher than that in the low-metastasis HepG2 potential cell line, and Tex10 expression in liver cancer stem cells was also higher than that in adhered HCC cells. In addition, Tex70 knockdown decreased stem cell marker expression and drug resistance. Tex10 promoted cancer sternness through activation of the STAT3 signaling pathway. Taken together, our study demonstrates that Tex10 plays a potent carcinogenic role in HCC tumorigenesis by maintaining cancer stem cell properties through activation of the STAT3 signaling pathway and promoting chemo-resistance. Thus, targeting Tex10 may provide a novel and effective therapeutic strategy to suppress the tumorigenicity of advanced HCC.
机译：据报道，睾丸表达了10（TEX10），是多能电路的新核心组分，以积极调节胚胎干细胞（ESC）超强子，以促进ESC自我更新;然而，TEX10在肝细胞癌（HCC）和肝癌干细胞中的表达和功能仍然不清楚。本研究旨在探讨来自HCC患者和HCC细胞系中的样品中的TEX10的表达模式，WERP样品中的样品。得到的结果表明，TEX10在HCC组织中高度表达，并且升高的TEX10蛋白质水平与差异差异化的癌呈正相关。同样，我们发现，高转移HcClM3潜在细胞系中的Tex10表达高于低转移HepG2潜在细胞系中的表达，肝癌干细胞中的Tex10表达也高于粘附的HCC细胞中的Tex10表达。此外，Tex70敲低降低干细胞标志物表达和耐药性。 Tex10通过激活Stat3信号通路促进癌症静止。我们的研究表明，通过活化STAT3信号通路并促进化学抗性，TEX10通过维持癌症干细胞性能并通过激活癌症干细胞性能并促进化学抗性，Tex10在HCC肿瘤肿瘤中发挥有效的致癌作用。因此，靶向TEX10可以提供一种新颖的和有效的治疗策略来抑制晚期HCC的致瘤性。

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  • 来源
    《Cell cycle》 |2018年第11期|共9页
  • 作者

    Xiang Xiaocong; Deng Li; Xiong Rong; Xiao Dongqin; Chen Zhu; Yang Fei; Liu Kang; Feng Gang;

  • 作者单位

    North Sichuan Med Coll Nanchong Cent Hosp Inst Tissue Engn &

    Stem Cells Clin Med Coll 2;

    North Sichuan Med Coll Nanchong Cent Hosp Inst Tissue Engn &

    Stem Cells Clin Med Coll 2;

    North Sichuan Med Coll Nanchong Cent Hosp Inst Tissue Engn &

    Stem Cells Clin Med Coll 2;

    North Sichuan Med Coll Nanchong Cent Hosp Inst Tissue Engn &

    Stem Cells Clin Med Coll 2;

    North Sichuan Med Coll Nanchong Cent Hosp Inst Tissue Engn &

    Stem Cells Clin Med Coll 2;

    North Sichuan Med Coll Nanchong Cent Hosp Inst Tissue Engn &

    Stem Cells Clin Med Coll 2;

    North Sichuan Med Coll Nanchong Cent Hosp Inst Tissue Engn &

    Stem Cells Clin Med Coll 2;

    North Sichuan Med Coll Nanchong Cent Hosp Inst Tissue Engn &

    Stem Cells Clin Med Coll 2;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Hepatocellular carcinoma; Tex10; cancer stem cell; chemoresistance; STAT3 signaling;

    机译：肝细胞癌;TEX10;癌症干细胞;化学抑制;Stat3信令;

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