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Elevated expression of NFE2L3 predicts the poor prognosis of pancreatic cancer patients

机译：NFE2L3的升高表达预测胰腺癌患者的预后差

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摘要

The highly malignant feature and difficulties for early diagnosis are the key reasons contributing to the poor prognosis of pancreatic cancer (PC) patients. NFE2L3 is a nuclear transcription factor, which has been reported an important biomarker of several tumors. But the role of NFE2L3 in PC remained undefined. Herein, through qPCR and immunohistochemistry, we found a significantly increased NFE2L3 in PC tissues as compared with adjacent non-tumor tissues. While reducing NFE2L3 expression suppressed the invasion abilities of PC cells, elevated NFE2L3 was found associated with lymph node metastasis (P = 0.001; HR=3.95; 95% CI: 1.70 - 9.17) and advanced TNM stages (P 0.001; HR = 4.06; 95% CI: 1.74 - 9.46). Consistently, data from both our two cohorts and the TCGA database revealed that higher NFE2L3 PC carriers had worse outcomes than those lower NFE2L3 expressers. Lastly, we confirmed the regulatory role of NFE2L3 on VEGFA, an important player involved in tumor angiogenesis. Collectively, our investigations suggested the oncogenic role of NFE2L3 in PC development and provided the rational for future adding NFE2L3 for the risk assessment of PC patients.
机译：早期诊断的高度恶性特征和困难是有助于胰腺癌（PC）患者不良的主要原因。 NFE2L3是一种核转录因子，据报道了几种肿瘤的重要生物标志物。但是NFE2L3在PC中的作用保持不确定。这里，通过QPCR和免疫组织化学，与相邻的非肿瘤组织相比，我们发现PC组织中的NFE2L3显着增加。在减少NFE2L3表达抑制PC细胞的侵袭能力的同时，发现升高的NFE2L3与淋巴结转移相关（P = 0.001; HR = 3.95; 95％CI：1.70-9.17）和高级TNM阶段（P <0.001; HR = 4.06; 95％CI：1.74 - 9.46）。一致地，来自我们两个队列和TCGA数据库的数据显示，较高的NFE2L3 PC载体比下部NFE2L3表达者更差。最后，我们确认了NFE2L3对VEGFA的监管作用，这是肿瘤血管生成的重要参与者。统称，我们的调查表明NFE2L3在PC开发中的致癌作用，并为未来添加了NFE2L3的理性作用，用于PC患者的风险评估。

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  • 来源
    《Cell cycle》 |2018年第17期|共11页
  • 作者

    Wang Hui; Zhan Ming; Yang Ruimeng; Shi Yongheng; Liu Qiang; Wang Jian;

  • 作者单位

    Shanghai Jiao Tong Univ Sch Med Renji Hosp Dept Biliary Pancreat Surg Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Renji Hosp Dept Biliary Pancreat Surg Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Shanghai Peoples Hosp 9 Core Lab Med Ctr Clin Res Dept;

    Shanghai Jiao Tong Univ Sch Med Renji Hosp Dept Pathol Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Renji Hosp Dept Pathol Shanghai Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Renji Hosp Dept Biliary Pancreat Surg Shanghai Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Pancreatic cancer; NFE2L3; VEGFA; prognosis; biomarker;

    机译：胰腺癌;NFE2L3;VEGFA;预后;生物标志物;

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