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首页> 外文期刊>Cell cycle >Upregulation of mRNA in MAPK signaling: transcriptional activation or mRNA stabilization?
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Upregulation of mRNA in MAPK signaling: transcriptional activation or mRNA stabilization?

机译：MAPK信号传导中mRNA的上调：转录激活或mRNA稳定化？

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Mitogen-activated protein kinases (MAPKs), found in all eukaryotes, are signal-transducing enzymes that play a central role in a variety of biological processes. MAPK phosphatase has dual catalytic activity toward phosphotyrosine- and phosphothreonine-containing proteins, and is known to inactivate ERKs and JNKs/SAPKs, thus playing a crucial role in MAPK regulation. Although MAPK phosphatase has been implicated in a feedback loop that inactivates MAPKs after stimulation by mitogens and during the cellular response to stress, signaling pathways leading to MAPK phosphatase gene expression have not been fully elucidated. Recently, we have shown that a novel RNA-binding protein Rnc1 plays a crucial role in negative feedback regulation of MAPK signaling by stabilizing the mRNA of a MAPK phosphatase at the post-transcriptional level. One important aspect of our findings is that the increase in mRNA levels involves not only the transcriptional upregulation, but also the post-transcriptional gene regulation, especially the regulation of mRNA stability. Our discovery highlights a potential role and an emerging view of RNA-binding protein as a regulator of cell signaling and as a future target of drug discovery.
机译：在所有真核生物中发现的丝裂原激活的蛋白激酶（MAPK）是信号转换酶，其在各种生物过程中起着核心作用。 MAPK磷酸酶具有朝向磷酸核苷酸和磷酸氨基醌蛋白的双催化活性，并且已知在MAPK调节中起着至关重要的作用。尽管MAPK磷酸酶涉及反馈回路，其在通过丝率刺激后灭活MAPK，并且在对应力的细胞响应期间，导致MAPK磷酸酶基因表达的信号传导途径尚未得到完全阐明。最近，我们已经表明，通过在转录后水平稳定MAPK磷酸酶的mRNA的MAPK信号传导的负反馈调节中，新的RNA结合蛋白RNC1在MAPK信号传导中起着至关重要的作用。我们研究结果的一个重要方面是MRNA水平的增加不仅涉及转录上调，而且涉及转录后基因调节，尤其是mRNA稳定性的调节。我们的发现突出了RNA结合蛋白作为细胞信号传导调节剂的潜在作用和新兴视图，作为药物发现的未来目标。

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