Cdk2 as a master of S phase entry: fact or fake?

Aleem E; Berthet C; Kaldis P

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Cdk2 as a master of S phase entry: fact or fake?

机译：CDK2作为S相条目的主人：事实或假货？

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It has long been believed that Cdk2 and its activator cyclin E play essential roles in the progression of the mitotic cell cycle. However, recent studies using knockout mouse models revealed that neither Cdk2 nor cyclin E are essential in vivo. The purpose of this Perspective is to compare both Cdk2 and cyclin E knockout mice models and to discuss potential mechanisms driving the cell cycle in the absence of Cdk2 or cyclin E. Particular emphasis is placed on possible non-catalytic roles of cyclin E, the expression and activity of the second cyclin binding partner of Cdk2, cyclin A, as well as on the expression and degradation of the Cdk2 inhibitor p27Kip1 in the absence of Cdk2.

机译：已经据信CDK2及其活化剂Cyclin E在有丝分裂细胞周期的进展中起主要作用。然而，最近使用淘汰鼠标模型的研究表明，CDK2和Cyclin E都不是体内必不可少的。这种观点的目的是比较CDK2和Cyclin E敲除小鼠模型，并讨论在没有CDK2或细胞周期蛋白E的情况下驱动细胞周期的潜在机制。特别强调是对细胞周期蛋白E的可能性的非催化作用，表达式 CDK2，细胞周期蛋白A，Cyclin A的第二细胞周期蛋白结合伴侣的活性以及CDK2抑制剂P27KIP1在不存在CDK2的情况下的表达和降解。

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来源
《Cell cycle》 |2004年第1期|共3页
作者
Aleem E; Berthet C; Kaldis P;
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作者单位

National Cancer Institute Regulation of Cell Growth Laboratory Frederick Maryland 21702-1201 USA.;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
CDC2-CDC28 Kinases; Cell Cycle Proteins; Cyclin E; S Phase; Tumor Suppressor Proteins; 细胞周期蛋白质类; 细胞周期蛋白E; S期;

机译：CDC2-CDC28 Kinases;Cell Cycle Proteins;Cyclin E;S Phase;Tumor Suppressor Proteins;细胞周期蛋白质类;细胞周期蛋白E;S期;

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1. Cdk2 as a master of S phase entry: fact or fake? [J] . Aleem E, Berthet C, Kaldis P Cell cycle . 2004,第1期

机译：CDK2作为S相条目的主人：事实或假货？
2. Long-term 17alpha-ethinyl estradiol treatment decreases cyclin E and cdk2 expression, reduces cdk2 kinase activity and inhibits S phase entry in regenerating rat liver. [J] . Koroxenidou L, Ohlson LC, Porsch Hallstrom I Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2005,第3期

机译：长期17α-炔雌醇治疗可降低细胞周期蛋白E和cdk2的表达，降低cdk2激酶的活性，并抑制再生大鼠肝脏中S期的进入。
3. Interphase APC/C–Cdc20 inhibition by cyclin A2–Cdk2 ensures efficient mitotic entry [J] . Jamin B. Hein, Jakob Nilsson Nature Communications . 2016,第1期

机译：细胞周期蛋白A2-Cdk2对相间APC / C-Cdc20的抑制作用可确保有效的有丝分裂进入
4. Using Fake Cursors to Secure On-Screen Password Entry [C] . Alexander De Luca, Emanuel von Zezschwitz, Laurent Pichler, Annual CHI conference on human factors in computing systems . 2013

机译：使用伪光标保护屏幕密码输入
5. MASTERED IRONY: THE POINT OF ENTRY INTO A POST-CRITICAL EPISTEMOLOGY. [D] . CANNON, DALE WAYNE. 1969

机译：掌握的讽刺：进入批判性后流行病学的要点。
6. The Cyclin E/Cdk2 Substrate p220NPAT Is Required for S-Phase Entry Histone Gene Expression and Cajal Body Maintenance in Human Somatic Cells [O] . Xin Ye, Yue Wei, Grzegorz Nalepa, 2003

机译：细胞周期蛋白E / Cdk2底物p220NPAT是人体细胞S阶段进入组蛋白基因表达和Cajal体维持所必需的
7. Cdk2 as a Master of S phase Entry: Fact or Fake? [O] . Eiman Aleem, Cyril Berthet, Philipp Kaldis 2004

机译：CDK2作为S相条目的主人：事实或假货？

Cdk2 as a master of S phase entry: fact or fake?

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