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首页> 外文期刊>Cell cycle >Proliferating tumor cells mimick glucose metabolism of mature human erythrocytes
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Proliferating tumor cells mimick glucose metabolism of mature human erythrocytes

机译：增殖肿瘤细胞模拟成熟人红细胞的葡萄糖代谢

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Mature human erythrocytes are dependent on anerobic glycolysis, i.e. catabolism (oxidation) of one glucose molecule to produce two ATP and two lactate molecules. Proliferating tumor cells mimick mature human erythrocytes to glycolytically generate two ATP molecules. They deliberately avoid or switch off their respiration, i.e. tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS) machinery and consequently dispense with the production of additional 36 ATP molecules from one glucose molecule. This phenomenon is named aerobic glycolysis or Warburg effect. The present review deals with the fate of a glucose molecule after entering a mature human erythrocyte or a proliferating tumor cell and describes why it is useful for a proliferating tumor cell to imitate a mature erythrocyte. Blood consisting of plasma and cellular components (99% of the cells are erythrocytes) may be regarded as a mobile organ, constantly exercising a direct interaction with other organs. Therefore, the use of drugs, which influences the biological activity of erythrocytes, has an immediate effect on the entire organism.
机译：成熟的人红细胞依赖于一种葡萄糖分子的分解代谢（氧化）产生两种ATP和两个乳酸分子的分解代谢（氧化）。增殖肿瘤细胞模仿成熟的人红细胞，以甘油族产生两种ATP分子。它们故意避免或关闭它们的呼吸，即三羧酸（TCA）循环和氧化磷酸化（毒物）机械，因此从一个葡萄糖分子中产生另外的36个ATP分子。这种现象被命名为有氧糖酵解或Warburg效果。本综述在进入成熟的人红细胞或增殖肿瘤细胞后涉及葡萄糖分子的命运，并描述了为什么它可用于模拟成熟红细胞的增殖肿瘤细胞。由等离子体和细胞组分组成的血液（99％的细胞是红细胞）可以被视为移动器官，不断与其他器官均匀互动。因此，利用影响红细胞生物活性的药物对整个生物体产生立即影响。

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