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CASC CASC 2: An emerging tumour‐suppressing long noncoding RNA RNA in human cancers and melanoma

机译：Casc Casc 2：人类癌症和黑色素瘤中出现的肿瘤抑制长的无量子RNA

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摘要

Abstract Deregulation of long noncoding RNA s (lnc RNA s) has been implicated in tumourigenesis. Cancer Susceptibility Candidate 2 ( CASC 2) is a lnc RNA downregulated in multiple cancer types, including endometrial, lung, gastric and colorectal cancers. CASC 2 functions as a tumour‐suppressive lnc RNA though multiple mechanisms, such as sequestration of oncogenic micro RNA s and repression of Wnt/β‐catenin signalling. Pertinent to clinical practice, the use of CASC 2 as a prognostic marker has been demonstrated in sporadic studies. These findings suggested that CASC 2 might play an important role in human cancers and melanoma. More efforts are warranted to examine the function role of CASC 2 in other cancer types. Further validation is also needed to promote its development to be a clinically utilizable prognostic biomarker.
机译：摘要长度非划分RNA S（LNC RNA S）的放松统计在肿瘤内具有含义。 癌症敏感性候选2（CASC 2）是在多种癌症类型中下调的LNC RNA，包括子宫内膜，肺，胃和结肠直肠癌。 Casc 2用作肿瘤抑制LNC RNA，虽然多种机制，例如致癌微RNA S的螯合和Wnt /β-catenin信号传导的抑制。 与临床实践有关，在散发性研究中已经证明了Casc 2作为预后标志物的使用。 这些研究结果表明CASC 2可能在人类癌症和黑色素瘤中发挥重要作用。 需要更多的努力来检查Casc 2在其他癌症类型中的功能作用。 还需要进一步验证来促进其发展成为临床可利用的预后生物标志物。

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  • 来源
    《Cell Proliferation》 |2018年第6期|共5页
  • 作者

    Yu Xin; Zheng Heyi; Tse Gary; Zhang Lin; Wu William Ka Kei;

  • 作者单位

    Department of DermatologyPeking Union Medical College Hospital Chinese Academy of Medical Sciences;

    Department of DermatologyPeking Union Medical College Hospital Chinese Academy of Medical Sciences;

    Department of Medicine and TherapeuticsThe Chinese University of Hong KongShatin Hong Kong;

    Department of Anaesthesia and Intensive CareThe Chinese University of Hong KongShatin Hong Kong;

    Department of Anaesthesia and Intensive CareThe Chinese University of Hong KongShatin Hong Kong;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    lnc RNA; melanoma; prognostic marker; tumour suppressor;

    机译：LNC RNA;黑色素瘤;预后标志物;肿瘤抑制剂;

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