Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy

Lechner Andrew J.; Driver Ian H.; Lee Jinwoo; Conroy Carmen M.; Nagle Abigail; Locksley Richard M.; Rock Jason R.

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Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy

机译：招募单核细胞和2型免疫促进肺切除术后的肺再生

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To investigate the role of immune cells in lung regeneration, we used a unilateral pneumonectomy model that promotes the formation of new alveoli in the remaining lobes. Immunofluorescence and single-cell RNA sequencing found CD115+ and CCR2+ monocytes and M2-like macrophages accumulating in the lung during the peak of type 2 alveolar epithelial stem cell (AEC2) proliferation. Genetic loss of function in mice and adoptive transfer studies revealed that bone marrow-derived macrophages (BMDMs) traffic to the lung through a CCL2-CCR2 chemokine axis and are required for optimal lung regeneration, along with Il4ra-expressing leukocytes. Our data suggest that these cells modulate AEC2 proliferation and differentiation. Finally, we provide evidence that group 2 innate lymphoid cells are a source of IL-13, which promotes lung regeneration. Together, our data highlight the potential for immunomodulatory therapies to stimulate alveologenesis in adults.

机译：为了探讨免疫细胞在肺再生中的作用，我们使用单侧肺切除术模型，促进剩余的裂片中的新肺泡的形成。免疫荧光和单细胞RNA测序发现CD115 +和CCR2 +单核细胞和M2样巨噬细胞在2型肺泡上皮干细胞（AEC2）增殖中的峰值期间积聚在肺中。小鼠和养级转移研究中功能的遗传丧失揭示了通过CCl2-CCR2趋化因子轴线的骨髓衍生的巨噬细胞（BMDMS）流量，并且是最佳的肺再生所需的肺再生，以及表达IL4ARA表达的白细胞。我们的数据表明，这些细胞调节AEC2增殖和分化。最后，我们提供了第2组先天淋巴细胞的证据，是IL-13的来源，促进肺再生。我们的数据在一起突出了免疫调节治疗刺激成人肺动力学疗法的可能性。

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《Cell stem cell》 |2017年第1期|共22页
作者
Lechner Andrew J.; Driver Ian H.; Lee Jinwoo; Conroy Carmen M.; Nagle Abigail; Locksley Richard M.; Rock Jason R.;
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Univ Calif San Francisco Dept Anat San Francisco CA 94143 USA;

Univ Calif San Francisco Dept Anat San Francisco CA 94143 USA;

Univ Calif San Francisco Dept Med San Francisco CA 94143 USA;

Univ Calif San Francisco Dept Anat San Francisco CA 94143 USA;

Univ Calif San Francisco Dept Anat San Francisco CA 94143 USA;

Univ Calif San Francisco Dept Med San Francisco CA 94143 USA;

Univ Calif San Francisco Dept Anat San Francisco CA 94143 USA;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
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1. Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy [J] . Lechner Andrew J., Driver Ian H., Lee Jinwoo, Cell stem cell . 2017,第1期

机译：招募单核细胞和2型免疫促进肺切除术后的肺再生
2. Ly-6C(high) inflammatory-monocyte recruitment is regulated by p38 MAPK/MCP-1 activation and promotes ventilator-induced lung injury [J] . International immunopharmacology . 2020,第期

机译：LY-6C（高）炎症 - 单核细胞募集受P38 MAPK / MCP-1激活并促进呼吸机诱导的肺损伤
3. Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma [J] . Zas?onaZ., PrzybranowskiS., WilkeC., The Journal of Immunology: Official Journal of the American Association of Immunologists . 2014,第8期

机译：在哮喘小鼠模型中，常存在的肺泡巨噬细胞抑制，而募集的单核细胞则促进了过敏性肺部炎症
4. Platelet-microparticles as a transcellular delivery system for RANTES promoting monocyte recruitment on inflamed and atherosclerotic endothelium [C] . S. R Mause, R von Hundelshausen, A. Zerneck Nordrhein-Westfa?lische Akademie der Wissenschaften . 2005

机译：血小板微粒作为横瓣递送系统，用于促进发炎和动脉粥样硬化内皮的单核细胞募集
5. Recruited Monocytes and Type 2 Cytokines Promote Lung Regeneration [D] . Lechner, Andrew J. 2017

机译：募集的单核细胞和2型细胞因子促进肺再生
6. Recruited monocytes and Th2 cytokine signaling promote lung regeneration following pneumonectomy [O] . Andrew J. Lechner, Ian H. Driver, Jinwoo Lee, -1

机译：肺切除术后募集的单核细胞和Th2细胞因子信号促进肺再生
7. Type I IFNs Are Required to Promote Central Nervous System Immune Surveillance through the Recruitment of Inflammatory Monocytes upon Systemic Inflammation [O] . Javier María Peralta Ramos, Claudio Bussi, Emilia Andrea Gaviglio, 2017

机译：通过在全身性炎症中募集炎性单核细胞，I型IFN是必需的，以促进中枢神经系统免疫监测

Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy

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