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首页> 外文期刊>Cytopathology >Diffuse sclerosing variant of papillary thyroid carcinoma: A study of fine needle aspiration cytology in 20 patients
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Diffuse sclerosing variant of papillary thyroid carcinoma: A study of fine needle aspiration cytology in 20 patients

机译：乳头状甲状腺癌的弥漫性硬化变异：20例细针穿刺细胞学研究

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Background: A diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is a rare variant and reports describing the cytological findings are few. Patients and Methods: We studied 24 cytological samples from thyroid fine needle aspirates of 20 patients with DSV-PTC. The specimens were taken from 14 non-nodular lesions and 10 nodules. Results: All aspirates taken from both non-nodular lesions and nodules had sufficient cellularity. The carcinoma cells frequently (70-100%) appeared as solid cell balls and hollow balls, and showed a hobnail pattern, squamous differentiation, septate cytoplasmic vacuoles and large unilocular vacuoles. Most of the carcinoma cells seem to be taken from the lumen of dilated lymph vessels. Ground glass nuclear chromatin, intranuclear cytoplasmic inclusions and grooved nuclei were infrequent (50% or less). In the background, a large number of lymphocytes and abundant psammoma bodies were almost always seen. Conclusions: Cytological findings of DSV-PTC are as follows: (1) solid cell balls and/or hollow balls containing lymphocytes; (2) hobnail cells; (3) septate cytoplasmic vacuoles; (4) large unilocular vacuoles; (5) squamous differentiation; (6) abundant psammoma bodies; (7) lymphocytic background; and (8) the absence or relative lack of characteristic nuclear features of papillary carcinoma. When DSV-PTC is suspected by ultrasound examination, the aspiration cytology from a non-nodular area of the thyroid can led us to the diagnosis of the variant.
机译：背景：乳头状甲状腺癌的弥漫性硬化变体（DSV-PTC）是一种罕见变体，描述细胞学发现的报道很少。患者和方法：我们研究了20例DSV-PTC患者的甲状腺细针抽吸物中的24份细胞学样品。标本取自14个非结节性病变和10个结节。结果：所有从非结节性病变和结节中取出的抽吸物均具有足够的细胞性。癌细胞经常（70-100％）以实心细胞球和空心球的形式出现，并显示出钉状，鳞状分化，分隔的细胞质液泡和大的单眼液泡。大多数癌细胞似乎取自扩张的淋巴管腔。毛玻璃核染色质，核内胞质内含物和槽状核很少见（50％或更少）。在背景中，几乎总是可以看到大量的淋巴细胞和大量的肺腺瘤体。结论：DSV-PTC的细胞学发现如下：（1）含有淋巴细胞的固体细胞球和/或空心球。 （2）指甲细胞; （3）分隔胞质液泡; （4）单眼大液泡; （5）鳞状分化; （6）丰富的肺腺瘤体; （7）淋巴细胞本底; （8）缺乏或相对缺乏乳头状癌的特征性核特征。当通过超声检查怀疑DSV-PTC时，甲状腺非结节区域的抽吸细胞学检查可以使我们诊断出该变异。

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