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Diverse structures, functions and uses of FK506 binding proteins

机译：FK506结合蛋白的不同结构，功能和用途

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摘要

FK506 (Tacrolimus), isolated from Streptomyces tsukubaenis is a powerful immunosuppressant shown to inhibit T cell activation. FK506 mediated immunosuppression requires the formation of a complex between FK506, a FK506 binding protein (FKBP) and calcineurin. Numerous FKBPs have been identified in a wide range of species, from single celled organisms to humans. FKBPs show peptidylprolyl cis/trans isomerase (PPIase) activity and have been shown to affect a wide range of cellular processes including protein folding, receptor signaling and apoptosis. FKBPs also affect numerous biological functions in addition to immunosuppression including regulation of cardiac function, neuronal function and development and have been implicated in several diseases including cardiac disease, cancer and neurodegenerative diseases such as Alzheimer's disease. More recently, FKBPs have proven useful as molecular tools for studying protein interactions, localization and functions. This review provides an overview of the current state of knowledge of FKBPs and their numerous biological functions and uses.
机译：来自Streptomyces Tsukubaenis的FK506（Tacrolimus）是一种强大的免疫抑制剂，显示为抑制T细胞活化。 FK506介导的免疫抑制需要形成FK506，FK506结合蛋白（FKBP）和钙蛋白之间的复合物。许多FKBPS已在各种物种中鉴定，从单纤维的生物到人类。 FKBPS显示肽基脯氨酸CIS /反式异构酶（PPIASE）活性，并且已被证明以影响众多细胞过程，包括蛋白质折叠，受体信号和凋亡。除免疫抑制外，FKBPS还影响了许多生物学功能，包括调节心功能，神经元功能和发育，并涉及多种疾病，包括心脏病，癌症和神经变性疾病，如阿尔茨海默病。最近，FKBPS已被证明是用于研究蛋白质相互作用，本地化和功能的分子工具。本综述概述了FKBPS的当前知识状态及其许多生物功能和用途。

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