PLEKHO2 is essential for M-CSF-dependent macrophage survival

Zhang Pengfei; Zhou Chenchen; Lu Cheng; Li Wenfei; Li Wei; Jing Bin; Chen Wenxia; Zha Yuhua; Zhang Peng; Bai Changqin; Liu Huiying; Zhang Luo

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PLEKHO2 is essential for M-CSF-dependent macrophage survival

机译：Plekho2对M-CSF依赖性巨噬细胞生存至关重要

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Macrophage-colony stimulating factor (M-CSF) is crucial for macrophage survival; however, the mechanism associated with this signaling has not been fully elucidated. Here, we identified pleckstrin homology domain containing family O member 2 (PLEKHO2), a protein with unknown function, as a novel regulator of macrophage survival in vitro and in vivo. We found that PLEKHO2-deficient mice exhibited severe reductions in macrophage population in the peritoneal cavity, spleen, and blood, and that PLEKHO2 expression was upregulated during macrophage differentiation and maturation. Additionally, PLEKHO2-deficient bone marrow derived macrophages displayed increased apoptotic cell death in the absence of M-CSF, although PLEKHO2 deficiency did not affect macrophage differentiation and proliferation. Furthermore, although signaling pathways downstream of M-CSF appeared unaffected, caspase activation was elevated in PLEKHO2-deficient macrophages. Our results provided genetic evidence of roles for PLEKHO2 in promoting macrophage survival.

机译：巨噬细胞殖民地刺激因子（M-CSF）对于巨噬细胞存活至关重要;然而，与该信号传导相关的机制尚未完全阐明。在此，我们鉴定了含有族成员2（Plekho2）的Pleckstrin同源域，一种具有未知功能的蛋白质，作为体外和体内巨噬细胞存活的新型调节因素。我们发现Plekho2缺陷小鼠在腹膜腔内，脾脏和血液中的巨噬细胞群体表现出严重减少，并且在巨噬细胞分化和成熟过程中上调了Plekho2表达。此外，Plekho2缺乏骨髓衍生的巨噬细胞在没有M-CSF的情况下显示出增加的凋亡细胞死亡，尽管Plekho2缺乏不影响巨噬细胞分化和增殖。此外，尽管M-CSF下游的信号传导途径不受影响，但在Plekho2缺陷型巨噬细胞中升高了胱天蛋酶活化。我们的结果为Plekho2在促进巨噬细胞存活方面提供了遗传证据。

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来源
《Cellular Signalling》 |2017年第2017期|共8页
作者
Zhang Pengfei; Zhou Chenchen; Lu Cheng; Li Wenfei; Li Wei; Jing Bin; Chen Wenxia; Zha Yuhua; Zhang Peng; Bai Changqin; Liu Huiying; Zhang Luo;
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作者单位

Chinese PLA 307 Hosp Dept Biomed Engn Beijing 100071 Peoples R China;

Chinese PLA 307 Hosp Dept Biomed Engn Beijing 100071 Peoples R China;

Chinese PLA 307 Hosp Dept Biomed Engn Beijing 100071 Peoples R China;

Chinese PLA 307 Hosp Dept Biomed Engn Beijing 100071 Peoples R China;

Chinese PLA 307 Hosp Dept Biomed Engn Beijing 100071 Peoples R China;

Chinese PLA 307 Hosp Dept Biomed Engn Beijing 100071 Peoples R China;

Chinese PLA 307 Hosp Dept Biomed Engn Beijing 100071 Peoples R China;

Chinese PLA 307 Hosp Dept Biomed Engn Beijing 100071 Peoples R China;

Chinese PLA 307 Hosp Dept Biomed Engn Beijing 100071 Peoples R China;

Chinese PLA 307 Hosp Dept Resp &

Crit Care Dis Beijing 100071 Peoples R China;

Chinese PLA 307 Hosp Dept Biomed Engn Beijing 100071 Peoples R China;

Chinese PLA 307 Hosp Dept Biomed Engn Beijing 100071 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类细胞形态学;
关键词
Macrophage survival; M-CSF; Caspase; PLEKHO2;

机译：巨噬细胞存活;m-csf;caspase;plekho2;

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专利

1. PLEKHO2 is essential for M-CSF-dependent macrophage survival [J] . Zhang Pengfei, Zhou Chenchen, Lu Cheng, Cellular Signalling . 2017,第期

机译：Plekho2对M-CSF依赖性巨噬细胞生存至关重要
2. Response gene to complement 32 （RGC-32） expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4 [J] . Peng Zhao12, Daiqing Gao2, Qingjie Wang1, 细胞与分子免疫学：英文版 . 2015,第006期

机译：在M2偏振和肿瘤相关巨噬细胞上补充32（RGC-32）表达的响应基因是M-CSF依赖性和增强的肿瘤衍生的IL-4
3. GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling [J] . Andrew J. Fleetwood, Hang Dinh, Andrew D. Cook Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2009,第2期

机译：依赖GM-CSF和M-CSF的巨噬细胞表型表现出对I型干扰素信号转导的不同依赖性
4. Survival-Expression Map and Essential Forms of Survival-Expression Relations for Genes [C] . Yajing Chen, Shikui Tu, Lei Xu International Conference on intelligent science and big data engineering . 2017

机译：生存-表达图和基因的生存-表达关系的基本形式
5. Monocyte / macrophage traffic plays an essential role in HIV and SIV pathogenesis. [D] . Campbell, Jennifer Helen. 2014

机译：单核细胞/巨噬细胞运输在HIV和SIV发病机理中起重要作用。
6. Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4 [O] . Peng Zhao, Daiqing Gao, Qingjie Wang, 2015

机译：M2极化和与肿瘤相关的巨噬细胞上补体32（RGC-32）表达的应答基因是M-CSF依赖性的并由肿瘤来源的IL-4增强
7. Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4 [O] . Peng Zhao, Daiqing Gao, Qingjie Wang, 2014

机译：在M2偏振和肿瘤相关巨噬细胞上补充32（RGC-32）表达的响应基因是M-CSF依赖性和增强的肿瘤衍生的IL-4

PLEKHO2 is essential for M-CSF-dependent macrophage survival

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