The relationship between phosphorylation status of focal adhesion kinases, molecular subtypes, tumour microenvironment and survival in patients with primary operable ductal breast cancer

Andisha Najla M.; McMillan Donald C.; Gujam Fadia J. A.; Roseweir Antonia; Edwards Joanne

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The relationship between phosphorylation status of focal adhesion kinases, molecular subtypes, tumour microenvironment and survival in patients with primary operable ductal breast cancer

机译：主要可操作导管乳腺癌患者局灶性粘合激酶，分子亚型，肿瘤微环境和存活的关系

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Background: Despite advances in therapies to treat breast cancer, over 100,000 patients die in the UK of this disease per year, highlighting the need to develop effect predictive and prognostic markers for patients with primary operable ductal breast cancer. Therefore, the aim of the present study was to examine the relationship between membranous, cytoplasmic and nuclear expression of focal adhesion kinase (phosphorylated at Y 397, Y 861 and Y 925), molecular subtypes, tumour microenvironment and survival in patients with primary operable ductal breast cancer.

机译：背景：尽管治疗治疗乳腺癌的疗法，但在英国这种疾病中患有10％的患者，突出了为初级可操作的导管乳腺癌患者开发效果预测性和预后标志物。因此，本研究的目的是检查局灶性粘附激酶（在Y 397，Y 861和Y 925），分子亚型，肿瘤微环境和初级可操作导管患者中存活的关系的关系乳腺癌。

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来源
《Cellular Signalling》 |2019年第2019期|共9页
作者
Andisha Najla M.; McMillan Donald C.; Gujam Fadia J. A.; Roseweir Antonia; Edwards Joanne;
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作者单位

Univ Glasgow Royal Infirm Acad Unit Surg Coll Med Vet &

Life Sci Glasgow Lanark Scotland;

Univ Glasgow Royal Infirm Acad Unit Surg Coll Med Vet &

Life Sci Glasgow Lanark Scotland;

Univ Glasgow Royal Infirm Acad Unit Surg Coll Med Vet &

Life Sci Glasgow Lanark Scotland;

Univ Glasgow Unit Gastrointestinal Canc &

Mol Pathol Inst Canc Sci Coll Med Vet &

Life Sci Glasgow Lanark Scotland;

Univ Glasgow Unit Gastrointestinal Canc &

Mol Pathol Inst Canc Sci Coll Med Vet &

Life Sci Glasgow Lanark Scotland;

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正文语种 eng
中图分类细胞形态学;
关键词
Focal adhesion kinase; Phosphorylation; Molecular subtypes; Tumour microenvironment; Breast cancer; Survival;

机译：焦粘连酶;磷酸化;分子亚型;肿瘤微环境;乳腺癌;生存;

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专利

1. The relationship between phosphorylation status of focal adhesion kinases, molecular subtypes, tumour microenvironment and survival in patients with primary operable ductal breast cancer [J] . Andisha Najla M., McMillan Donald C., Gujam Fadia J. A., Cellular Signalling . 2019,第期

机译：主要可操作导管乳腺癌患者局灶性粘合激酶，分子亚型，肿瘤微环境和存活的关系
2. The relationship between tumour budding, the tumour microenvironment and survival in patients with invasive ductal breast cancer [J] . F J A Gujam, D C McMillan, Z M A Mohammed, British Journal of Cancer . 2015,第7期

机译：浸润性导管癌患者肿瘤出芽，肿瘤微环境与生存的关系
3. The relationship between lymphovascular invasion and angiogenesis, hormone receptors, cell proliferation and survival in patients with primary operable invasive ductal breast cancer [J] . Zahra MA Mohammed, Donald C McMillan, Joanne Edwards, BMC Clinical Pathology . 2013,第1期

机译：原发性可操作性浸润性导管癌患者淋巴管侵犯与血管生成，激素受体，细胞增殖与存活之间的关系
4. Role of Soy Phytoestrogens Genistein and Daidzein in Focal Adhesion Assembly and Focal Adhesion Kinase Activity in Breast Cancer Cells [C] . Nicolas G. Azios, Suranganie F. Dharmawardhan International Symposium on Hormonal Carcinogenesis . 2005

机译：大豆植物雌二酮的作用与乳腺癌细胞局灶性粘附组装和局灶性粘附激酶活性的作用
5. Overexpression of the receptor tyrosine kinase EphA2 induces malignant transformation of benign mammary epithelia: Implication for increased cell survival and altered cellular adhesions in breast cancer. [D] . Zelinski, Daniel Paul. 2001

机译：受体酪氨酸激酶EphA2的过表达诱导了良性乳腺上皮的恶性转化：暗示增加细胞存活率和改变乳腺癌细胞粘附。
6. The relationship between components of tumour inflammatory cell infiltrate and clinicopathological factors and survival in patients with primary operable invasive ductal breast cancer [O] . Z MA Mohammed, J J Going, J Edwards, 2012

机译：原发性可操作性浸润性导管癌患者肿瘤炎症细胞浸润成分与临床病理因素与生存的关系
7. The relationship between phosphorylation status of focal adhesion kinases, molecular subtypes, tumour microenvironment and survival in patients with primary operable ductal breast cancer [O] . Najla M. Andisha, Donald C. McMillan, Fadia J.A. Gujam, 2019

机译：主要可操作导管乳腺癌患者局灶性粘合激酶，分子亚型，肿瘤微环境和存活的关系

The relationship between phosphorylation status of focal adhesion kinases, molecular subtypes, tumour microenvironment and survival in patients with primary operable ductal breast cancer

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