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首页> 外文期刊>Cell transplantation >Therapeutic Effects of Umbilical Cord Blood-Derived Mesenchymal Stem Cells Combined with Polydeoxyribonucleotides on Full-Thickness Rotator Cuff Tendon Tear in a Rabbit Model
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Therapeutic Effects of Umbilical Cord Blood-Derived Mesenchymal Stem Cells Combined with Polydeoxyribonucleotides on Full-Thickness Rotator Cuff Tendon Tear in a Rabbit Model

机译：脐带血渗间充质干细胞与聚氧氧化核苷酸联合兔兔模型全厚旋转胶带撕裂的治疗效果

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While therapies using mesenchymal stem cells (MSCs) to treat rotator cuff tendon tear (RCTT) have yielded some promising preliminary results, MSCs therapy has not yet completely regenerated full-thickness RCTT (FTRCTT). It has recently been reported that polydeoxyribonucleotide (PDRN) is effective in the treatment of chronic rotator cuff disease. We hypothesized that local injection of human umbilical cord blood-derived (UCB)-MSCs with PDRN would be more effective in regenerating tendon tear than UCB-MSCs alone. The purpose of this study was to evaluate the effects of UCB-MSCs combined with different doses of PDRN on the regeneration of RCTT in a chronic RCTT model by using a rabbit model. New Zealand white rabbits (n = 24) with FTRCTT were allocated randomly into three groups (8 rabbits per group). Three different injectants (G1-S, 0.2 mL UCB-MSCs; G2-P1, 0.2 mL UCB-MSCs with one injection of 0.2 mL PDRN; G3-P4, 0.2 mL UCB-MSCs, and four injections of 0.2 mL PDRN per week) were injected into FTRCTT under US-guidance. After the rabbits were euthanized, we evaluated ross morphological and histological change. Motion analysis was also performed. There were significant differences in gross morphological changes between before, and at 4 weeks after injection, in all three groups, but no differences were found among the three groups. Masson's trichrome (MT) or anti-type 1 collagen antibody (COL-1)-positive cell densities in G2-P1 and G3-P4 were improved significantly compared with those in G1-S, but showed no significant difference between G2-P1 and G3-P4. On motion analysis, walking distance and fast walking time in G2-P1 and G3-P4 were significantly longer/higher than those in G1-S, but showed no significant differences between G2-P1 and G3-P4. These results demonstrated that there was no significant difference in the gross morphologic change of tendon tear between UCB-MSCs only and combination with PDRN injection in rabbit model of chronic traumatic FTRCTT. Furthermore, there were no significant differences in the regenerative effects between high and low doses of (0.8 and 0.2) mL of PDRN.
机译：虽然使用间充质干细胞（MSCs）治疗旋转器箍筋撕裂（RCTT）的疗法产生了一些有前途的初步结果，但MSCs疗法尚未完全再生的全厚度RCTT（FTRCTT）。最近据报道，聚氧氧核苷酸（PDRN）在治疗慢性旋转器袖带疾病方面是有效的。我们假设具有PDRN的局部注射人脐血血液衍生（UCB）-MSCs在比UCB-MSCs单独的再生肌腱撕裂中更有效。本研究的目的是评估UCB-MSCs与不同剂量的PDRN联合在慢性RCTT模型中对慢性RCTT模型再生的影响。使用FTRCTT的新西兰白兔（N = 24）随机分配成三组（每组8只兔子）。三种不同的注射剂（G1-S，0.2mL UCB-MSCs; G2-P1，0.2mL UCB-MSCs，一次注射0.2mL PDRN; G3-P4，0.2mL UCB-MSCs，每周四次注射0.2ml PDRN ）根据美国的指导注入FTRCTT。在安乐死兔子后，我们评估了罗斯形态学和组织学变革。还进行了运动分析。在所有三组中，在注射后4周，在所有三组中，术后4周，在三组中，三组中没有发现差异存在显着差异。与G1-S中的G2-P1和G3-P4中的Masson的richrome（MT）或抗型胶原抗体（COL-1） - 阳性细胞密度显着提高，但在G2-P1和G3-S之间没有显着差异G3-P4。在运动分析中，G2-P1和G3-P4中的步行距离和快速步行时间明显更长/高于G1-S中的步行时间，但在G2-P1和G3-P4之间没有显着差异。这些结果表明，UCB-MSCs之间的肌腱撕裂的总体形态变化并与慢性创伤性FTRCTT的兔模型中的PDRN注射组合没有显着差异。此外，高低剂量（0.8和0.2）ml PDRN之间的再生效应没有显着差异。

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