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The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection

机译：纹章通过瞬间动作选择组织3D行为

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摘要

Many naturalistic behaviors are built from modular components that are expressed sequentially. Although striatal circuits have been implicated in action selection and implementation, the neural mechanisms that compose behavior in unrestrained animals are not well understood. Here, we record bulk and cellular neural activity in the direct and indirect pathways of dorsolateral striatum (DLS) as mice spontaneously express action sequences. These experiments reveal that DLS neurons systematically encode information about the identity and ordering of sub-second 3D behavioral motifs; this encoding is facilitated by fast-timescale decorrelations between the direct and indirect pathways. Furthermore, lesioning the DLS prevents appropriate sequence assembly during exploratory or odor-evoked behaviors. By characterizing naturalistic behavior at neural timescales, these experiments identify a code for elemental 3D pose dynamics built from complementary pathway dynamics, support a role for DLS in constructing meaningful behavioral sequences, and suggest models for how actions are sculpted over time.
机译：许多自然主义行为是由依次表达的模块化组件构建的。虽然纹状体电路已经涉及行动选择和实施，但是在无拘无束的动物中构成行为的神经机制也不太了解。在此，我们在背侧纹状体（DLS）的直接和间接途径中录制块状和细胞神经活性，作为自发性表达动作序列的小鼠。这些实验表明，DLS神经元系统地编码有关次秒3D行为图谱的身份和排序的信息;通过直接和间接途径之间的快速时间尺度去相关性促进此编码。此外，病变DLS在探索或气味诱发行为期间防止适当的序列组件。通过在神经时间尺度的自主行为，这些实验标识了由互补途径动态构建的元素3D构成动态的代码，支持DLS在构建有意义的行为序列方面的作用，并建议如何随时间雕刻操作的模型。

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