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首页> 外文期刊>Cell and tissue banking: An international journal of banking, engineering & transplantation of cells and tissues >Stability analysis of the antibiotic cocktail used by Treviso Tissue Bank Foundation for tissues decontamination
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Stability analysis of the antibiotic cocktail used by Treviso Tissue Bank Foundation for tissues decontamination

机译：Treviso组织银行基础用于组织去污的抗生素鸡尾酒的稳定性分析

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Although careful donor selection reduces tissue contamination, close microbiological control of harvested allografts remains a key task of tissue banks. To guarantee the safety of human tissues for allograft transplantation, a decontamination regimen must be adopted which, as recommended by European guidelines, is active against the majority of microorganisms isolated in tissues. Antibiotic decontamination methods differ from one tissue bank to another in terms of antimicrobial agents, temperature and length of exposure. After identifying the most effective antibiotics against the bacterial strains most commonly isolated in allografts, Treviso Tissue Bank Foundation demonstrated the efficacy of an antibiotic cocktail for tissue decontamination containing Gentamicin, Vancomycin and Meropenem. The aim of this study was to analyse the degradation kinetics of the three antibiotics according to preparation method and use. The results show that only Meropenem is unstable at +4 degrees C, while Gentamicin and Vancomycin are valid for over 10days. We thus established to add Meropenem before the start of the tissue decontamination phase.
机译：虽然仔细的供体选择减少了组织污染，但收获的同种异体移植物的密切微生物控制仍然是组织库的关键任务。为了保证人体组织的安全性进行同种异体移植移植，必须采用净化方案，如欧洲指南的建议，对组织中分离的大多数微生物都是活跃的。抗生素去污方法在抗微生物剂，温度和曝光长度方面与另一个组织库不同。在鉴定对抗同种异体植物中最常见的细菌菌株的最有效的抗生素后，Treviso组织库基金会展示了含有庆大霉素，万古霉素和梅洛宁的组织去污的抗生素鸡尾酒的功效。本研究的目的是根据制备方法和使用，分析三种抗生素的降解动力学。结果表明，只有梅洛宁在+ 4℃下才能不稳定，而庆大霉素和万古霉素在10天有效。因此，我们建立在组织去污阶段开始前添加梅洛宁。

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