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首页> 外文期刊>Cerebral cortex >Thalamocortical Afferents Innervate the Cortical Subplate much Earlier in Development in Primate than in Rodent
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Thalamocortical Afferents Innervate the Cortical Subplate much Earlier in Development in Primate than in Rodent

机译：Thalamocortical引义在灵长类动物中早期的啮齿动物初期地关联皮质偶数，而不是在啮齿动物中

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The current model, based on rodent data, proposes that thalamocortical afferents (TCA) innervate the subplate towards the end of cortical neurogenesis. This implies that the laminar identity of cortical neurons is specified by intrinsic instructions rather than information of thalamic origin. In order to determine whether this mechanism is conserved in the primates, we examined the growth of thalamocortical (TCA) and corticofugal afferents in early human and monkey fetal development. In the human, TCA, identified by secretagogin, calbindin, and ROBO1 immunoreactivity, were observed in the internal capsule of the ventral telencephalon as early as 7-7.5 PCW, crossing the pallial/subpallial boundary (PSB) by 8 PCW before the calretinin immunoreactive corticofugal fibers do. Furthermore, TCA were observed to be passing through the intermediate zone and innervating the presubplate of the dorsolateral cortex, and already by 10-12 PCW TCAs were occupying much of the cortex. Observations at equivalent stages in the marmoset confirmed that this pattern is conserved across primates. Therefore, our results demonstrate that in primates, TCAs innervate the cortical presubplate at earlier stages than previously demonstrated by acetylcholinesterase histochemistry, suggesting that pioneer thalamic afferents may contribute to early cortical circuitry that can participate in defining cortical neuron phenotypes.
机译：基于啮齿动物数据的当前模型提出了肌仿动作（TCA）在皮质神经发生的结束时将亚峰值分配。这意味着皮质神经元的层状标识由内在指令而不是丘脑起源的信息指定。为了确定这个机制是否在灵长类动物中保守，我们研究了早期人和猴胎发育中丘脑皮质（TCA）和皮质传统的生长。在腹斜腹的内部胶囊中观察到探测器，钙突蛋白和Robo1免疫反应性鉴定的人的TCA在腹侧诊断的内部胶囊中观察到7-7.5 pcW，在Calretinin免疫反应之前将Pallial / suballial边界（PSB）交叉8 pcW皮质雕塑纤维。此外，观察到TCA以通过中间区域并支配背侧皮质的假纸板，并且已经占据了10-12个PCW TCA占据了大量皮质。在Marmoset中的等效阶段的观察结果证实了这种模式在灵长类动物中保守。因此，我们的结果表明，在灵长类动物中，TCA在先前通过乙酰胆碱酯酶组织化学证明的先前阶段的皮质寄生术中的皮质寄存器分析，表明先驱丘脑传入可以有助于可以参与定义皮质神经元表型的早期皮质电路。

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