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首页> 外文期刊>Cerebral cortex >GH3 Controls Corpus Callosum Formation by Positioning Midline Guideposts During Telencephalic Patterning
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GH3 Controls Corpus Callosum Formation by Positioning Midline Guideposts During Telencephalic Patterning

机译：GH3通过定位在眼线图案中的中线导向柱进行控制胼callosum组

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The corpus callosum (CC) represents the major forebrain commissure connecting the 2 cerebral hemispheres. Midline crossing of callosal axons is controlled by several glial and neuronal guideposts specifically located along the callosal path, but it remains unknown how these cells acquire their position. Here, we show that the GH3 hypomorphic mouse mutant Polydactyly Nagoya (Pdn) displays agenesis of the CC and mislocation of the glial and neuronal guide-post cells. Using transplantation experiments, we demonstrate that agenesis of the CC is primarily caused by midline defects. These defects originate during telencephalic patterning and involve an up-regulation of Slit2 expression and altered Fgf and Wnt/p-catenin signaling. Mutations in sprouty1/2 which mimic the changes in these signaling pathways cause a disorganization of midline guide-posts and CC agenesis. Moreover, a partial recovery of midline abnormalities in Pdn/Pdn;Slit2~/~ embryos mutants confirms the functional importance of correct SIit2 expression levels for callosal development. Hence, GH3 controlled restriction of Fgf and Wnt/p-catenin signaling and of Slit2 expression is crucial for positioning midline guideposts and callosal development.
机译：语料库胼callosum（Cc）代表连接2个脑半球的主要前脑外壳。呼叫轴突的中线交叉由沿着召集路径特异性地定位的几个胶质和神经元指南来控制，但它仍然是这些细胞如何获取其位置的未知。在这里，我们表明GH3警长小鼠突变体多乳糖的名古屋（PDN）显示CC的验血和胶质和神经元引导细胞的误部。使用移植实验，我们证明了CC的验血主要是由中线缺陷引起的。这些缺陷源于眼光图案化，涉及释放SLIT2表达和改变的FGF和WNT / P-Catenin信号传导。 Sprouty1 / 2中的突变模仿这些信号传导途径的变化导致中线导柱和CC止血的紊乱。此外，PDN / PDN中的中线异常的部分恢复; SLIT2〜/〜胚胎突变体证实了衡量调用开发的正确SIIT2表达水平的功能重要性。因此，FGF和WNT / P-Catenin信号传导和SlIT2表达的GH3受控限制对于定位中线导向和调用开发至关重要。

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