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首页> 外文期刊>Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology >Association between herpes simplex virus Types 1 and 2 with cardiac myxoma
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Association between herpes simplex virus Types 1 and 2 with cardiac myxoma

机译：单纯疱疹病毒类型1和2之间的关联，用心肌肌瘤

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摘要

Most cases of atrial myxoma are sporadic, and the exact etiology is unknown. We examined if herpes simplex virus (HSV)-1 and HSV-2 antigens and/or DNA could be detected in a cohort of Iranian patients with cardiac myxomas. From July 2004 to June 2014, among a total of 36,703 patients undergoing open heart surgeries, consecutive patients with cardiac myxoma who were treated by surgical excision at our center included in this study. Of 73 patients studied, 56% were female with a mean age of 54 years (ranging from 23 to 77 years). Seventy-four myxomas were surgically removed from 73 patients, since one patient had two myxomas which were located on both the right atrium and right ventricle. The materials for this analysis were retrospectively gathered from extracted tumors that stored in a pathology bank of tissue paraffin blocks. The formalin fixed paraffin embedded tissue samples were investigated for HSV genomic DNA by both immunohistochemistry (IHC) and polymerase chain reaction (PCR) analysis. In all 74 cases there was no presence of HSV 1 and HSV 2 infection. This suggests that HSV may not play a role in sporadic cardiac myxomas; however, evidence for such association is currently lacking, and further studies are required to determine such a role. (C) 2016 Published by Elsevier Inc.
机译：大多数心房肌瘤病例是散发性的，并且确切的病因未知。如果疱疹病毒（HSV）-1和HSV-2抗原和/或DNA可以检测到伊朗肌瘤队患者的患者中，我们检查了。从2004年7月至2014年6月，共有36,703名患者接受开放的心脏病患者，连续患有心肌肌瘤的患者，在本研究中被我们的中心进行手术切除治疗。在73例患者中，56％的女性为54岁的平均年龄（23〜77岁）。从73名患者手术中删除了七十四只骨髓瘤，因为一名患者有两名肌瘤，位于右心房和右心室。回顾性地从储存在组织石蜡块的病理库中的提取肿瘤中回顾性地收集该分析的材料。通过免疫组织化学（IHC）和聚合酶链反应（PCR）分析，研究了福尔马林固定的石蜡嵌入组织样品进行HSV基因组DNA。在所有74例患者中，没有HSV 1和HSV 2感染存在。这表明HSV可能在散发性心肌肌瘤中不起作用;但是，目前缺乏这种协会的证据，需要进一步的研究来确定此类作用。 （c）2016年由elsevier公司发布

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