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How to resolve microsecond current fluctuations in single ion channels: The power of beta distributions

机译：如何解决单离子通道中的微秒电流波动：Beta分布的功率

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摘要

A main ingredient for the understanding of structure/function correlates of ion channels is the quantitative description of single-channel gating and conductance. However, a wealth of information provided from fast current fluctuations beyond the temporal resolution of the recording system is often ignored, even though it is close to the time window accessible to molecular dynamics simulations. This kind of current fluctuations provide a special technical challenge, because individual opening/closing or blocking/unblocking events cannot be resolved, and the resulting averaging over undetected events decreases the single-channel current. Here, I briefly summarize the history of fast-current fluctuation analysis and focus on the so-called beta distributions. This tool exploits characteristics of current fluctuation-induced excess noise on the current amplitude histograms to reconstruct the true single-channel current and kinetic parameters. A guideline for the analysis and recent applications demonstrate that a construction of theoretical beta distributions by Markov Model simulations offers maximum flexibility as compared to analytical solutions.
机译：用于理解离子通道的结构/功能相关的主要成分是单通道门控和电导的定量描述。但是，通常忽略从录音系统的时间分辨率超出超出时间分辨率的快速流动波动提供的信息，即使它接近分子动力学模拟的时间窗口。这种电流波动提供了一种特殊的技术挑战，因为单独的打开/关闭或阻塞/解锁事件不能解决，并且由未检测到的事件的产生平均降低了单通道电流。在这里，我简要概述了快速电流波动分析的历史，并专注于所谓的β发行版。该工具利用电流波动引起的多余噪声对电流幅度直方图的特性，以重建真正的单通道电流和动力学参数。分析和最近的应用的指导意见表明，与Markov模型模拟的理论测试版分布的构建提供了与分析解决方案相比的最大灵活性。

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