• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cephalalgia >Evidence of activation of vagal afferents by non-invasive vagus nerve stimulation: An electrophysiological study in healthy volunteers
【24h】

Evidence of activation of vagal afferents by non-invasive vagus nerve stimulation: An electrophysiological study in healthy volunteers

机译：非侵入性迷走神经刺激激活迷入引义的证据：健康志愿者的电生理学研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Benefits of cervical non-invasive vagus nerve stimulation (nVNS) devices have been shown in episodic cluster headache and preliminarily suggested in migraine, but direct evidence of vagus nerve activation using such devices is lacking. Vagal somatosensory evoked potentials (vSEPs) associated with vagal afferent activation have been reported for invasive vagus nerve stimulation (iVNS) and non-invasive auricular vagal stimulation. Here, we aimed to show and characterise vSEPs for cervical nVNS. Methods vSEPs were recorded for 12 healthy volunteers who received nVNS over the cervical vagus nerve, bipolar electrode/DS7A stimulation over the inner tragus, and nVNS over the sternocleidomastoid (SCM) muscle. We measured peak-to-peak amplitudes (P1-N1), wave latencies, and N1 area under the curve. Results P1-N1 vSEPs were observed for cervical nVNS (11/12) and auricular stimulation (9/12), with latencies similar to those described previously, whereas SCM stimulation revealed only a muscle artefact with a much longer latency. A dose-response analysis showed that cervical nVNS elicited a clear vSEP response in more than 80% of the participants using an intensity of 15?V. Conclusion Cervical nVNS can activate vagal afferent fibres, as evidenced by the recording of far-field vSEPs similar to those seen with iVNS and non-invasive auricular stimulation.
机译：宫颈无侵袭性迷宫神经刺激（NVNS）装置的背景已被显示为偏头痛，并且在偏头痛中初步提出，但缺乏使用这种装置的迷走神经激活的直接证据。据报道，迷入迷走神经刺激（IVNS）和非侵袭性耳廓迷离刺激的迷入传入激活相关的迷入躯体感觉诱发电位（VSEP）。在这里，我们旨在显示和表征宫颈NVN的vseps。方法为12种健康志愿者录制vseps，该志愿者接受颈椎神经，双极电极/ ds7a刺激的NVN，在内部痕迹和胸骨细胞肌瘤（SCM）肌肉上的NVN。我们测量曲线下的峰峰值幅度（P1-N1），波浪延迟和N1区域。结果观察到宫颈NVNS（11/12）和耳廓刺激（9/12）的P1-N1VSEPS，其潜伏类似于前面描述的那些，而SCM刺激仅揭示了一种具有更长延迟的肌肉艺术品。剂量 - 反应分析表明，使用15Ωv的强度，宫颈NVN在超过80％的参与者中引发了明确的VSEP响应。结论宫颈NVN可以激活缩小传入纤维，如vse场Vseps的记录所证明，类似于用IVNS和非侵入性耳廓刺激观察的那些。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号