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首页> 外文期刊>Chemical and Pharmaceutical Bulletin >Rapid Analysis of DOXIL Stability and Drug Release from DOXIL by HPLC Using a Glycidyl Methacrylate-Coated Monolithic Column
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Rapid Analysis of DOXIL Stability and Drug Release from DOXIL by HPLC Using a Glycidyl Methacrylate-Coated Monolithic Column

机译：HPLC使用甲基丙烯酸酯 - 丙烯酸缩水甘油酯整体柱快速分析DOXIL稳定性和药物释放

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In recent years, nanomedicines have received growing attention in a range of medical applications, including selective drug delivery technology. In this context, the analysis of liposome stability and drug release from liposomes is of particular importance, as the efficacy of a nanomedicine is determined by the release of the encapsulated drug. We investigated the influence of the surrounding environment on the stability and release of the encapsulated drug (i.e., doxorubicin) from DOXIL. Thus, for the purpose of this study, we selected the liposomal anticancer drug, DOXIL, as a typical nanomedicine, and investigated the influence of the surrounding environment on release of doxorubicin from DOXIL. We found that two pathways existed for doxorubicin release, namely the collapse of DOXIL, and an increase in the permeability of the lipid bilayer. DOXIL collapse occurred upon the addition of high concentrations (>60%) of a methanol solution, while an increase in permeability occurred at temperatures above the phase transition temperature of the DOXIL lipid bilayer, under basic conditions, and in the presence of membrane-permeable bases (e.g., Tris). As DOXIL is particularly stable and limited collapse of DOXIL occurred under physiological conditions, it is expected that doxorubicin release within the body took place through permeability changes in the lipid bilayer of the DOXIL structure.
机译：近年来，纳米胺在一系列医疗应用中受到影响，包括选择性药物递送技术。在这种情况下，由于纳米胺的效果通过包封的药物释放来确定脂质体稳定性和脂质体的药物释放的分析特别重要。我们调查了周围环境对从DOXIL封装药物（即多柔比星）的稳定性和释放的影响。因此，为了本研究的目的，我们选择了脂质体抗癌药物，DOXIL，作为典型的纳米胺，并研究了周围环境对从DOXIL释放过码霉素的影响。我们发现，对多柔比星释放的两种途径，即Doxil的崩溃，以及脂质双层的渗透性的增加。在加入高浓度（> 60％）甲醇溶液时发生Doxil崩溃，而在高于Doxil脂质双层的相变温度的温度下发生渗透性，在基本条件下，并且在膜渗透的存在下基础（例如，三）。由于DOXIL在生理条件下发生了尤其稳定，并且在生理条件下发生了有限的DOXIL，预计人体内的多柔比星释放通过DOXIL结构的脂质化双层的渗透性变化发生。

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