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首页> 外文期刊>Acta ophthalmologica Scandinavica >Systemic disease associations of familial and sporadic glaucoma: the Glaucoma Inheritance Study in Tasmania
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Systemic disease associations of familial and sporadic glaucoma: the Glaucoma Inheritance Study in Tasmania

机译：家族性和散发性青光眼的全身性疾病关联：塔斯马尼亚的青光眼遗传研究

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Background: This aim of this study was to compare the prevalence of various disease-associated and potentially modifiable risk factors between people with familial and sporadic forms of primary open angle glaucoma (OAG). Methods: A cross-sectional, retrospective study design was utilized. A detailed questionnaire enquiring about knowledge of family history, demographic data, current medications, and medical history of systemic disorders was administered. Where possible, living relatives were examined for signs of OAG. Results: A total of 3,800 potential patients with OAG were identified, of whom 2062 were examined. One thousand twelve (59.5%) subjects were found to have familial OAG, and 688 (40.5%) subjects had no known or identified relative with OAG (sporadic glaucoma). One thousand forty-two unaffected family members examined. A past history of migraine was found more often with familial OAG (OR: 1.67 95% CI: 1.15-2.42). This effect was primarily driven by patients who had a first-degree relative also affected by OAG. Following adjustment for male gender and the age at review, the presence of atherosclerosis was also found to be more common in patients with familial glaucoma than in people with sporadic disease (OR: 1.42 95% CI: 1.05-1.92). No significant difference in the prevalence of hypertension, Raynaud's phenomenon, diabetes mellitus or thyroid disease was identified. Conclusions: Patients with a known relative affected by OAG were statistically significantly more likely to have a past history for migraine or presence of atherosclerosis compared to people with no known affected relative. An understanding of such differences and systemic comorbidities will be useful for further work investigating the underlying molecular mechanisms of this disease.
机译：背景：本研究的目的是比较家族性和散发性原发性开角型青光眼（OAG）患者中各种与疾病相关和潜在可改变的危险因素的患病率。方法：采用横断面回顾性研究设计。进行了详细的问卷调查，询问有关家族病史，人口统计学数据，当前用药和系统性疾病病史的知识。在可能的情况下，对在世的亲属进行OAG体征检查。结果：共鉴定出3,800名潜在OAG患者，其中检查了2062名。发现1,112（59.5％）名受试者患有家族性OAG，而688（40.5％）名受试者没有OAG（散发性青光眼）的亲缘关系。一百四十二名未受影响的家庭成员接受了检查。家族性OAG的偏头痛病史较多（或：1.67 95％CI：1.15-2.42）。这种作用主要是由一级亲戚也受到OAG影响的患者引起的。在调整了男性和年龄后，发现家族性青光眼的患者比散发性疾病的人更常见（OR：1.42 95％CI：1.05-1.92）。高血压，雷诺现象，糖尿病或甲状腺疾病的患病率无明显差异。结论：与无已知亲戚的人相比，已知亲戚受OAG影响的患者有偏头痛或动脉粥样硬化病史的可能性更高。了解这种差异和系统性合并症将有助于进一步研究该疾病的潜在分子机制。

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