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首页> 外文期刊>Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers >Design of the reversible biphasic arrangement in the microfluidic chip reactor for asymmetric hydrogenation reactions
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Design of the reversible biphasic arrangement in the microfluidic chip reactor for asymmetric hydrogenation reactions

机译：微流体芯片反应器中可逆双相布置的设计对不对称氢化反应的影响

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摘要

Design of the reversible biphasic system for a practical use in asymmetric hydrogenation performed in a microfluidic chip reactor is reported. Methylacetoacetate (MAA) was transformed to (R)-methylhydroxybutyrate over optically pure (R)-Ru-BINAP as a model reaction. The study was an iteration towards the design, description and optimization of the temperature driven reversible biphasic system in the mixed [N-R,N-222][Tf2N]/methanol/water phase by varying the parameter of the structure of the ionic molecule, starting from [NH4][Tf2N] up to [N-14,N-222][Tf2N]. At temperatures, and other conditions providing high conversions and optical yields, the reaction mixture was monophasic. At lower temperatures, the mixture became biphasic for ionic liquids with long alkyl chains (namely [N-14,N-222][Tf2N]) due to their strong non-polar character. The formed ionic liquid phase accommodated the chiral Ru complex, the water/methanol phase the reaction products. After the reaction, when the mixture was cooled, over 90% of the catalytic complex was kept in the ionic liquid phase. Viscosity and density data were also discussed. It seems the reversible biphasic system offers a way to facilitate the separation of the chiral Ru-complex from the reaction mixture. Due to high sensitivity of the complex to handling conditions, its reuse still requires further optimization. (C) 2019 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
机译：报道了在微流体芯片反应器中进行的不对称氢化的可逆双相系统的设计。通过光学纯（R）-RU-BINAP作为模型反应，将甲基乙酰乙酸酯（MAA）转化为（R） - 甲基羟基丁酸酯。通过改变离子分子结构的参数，开始，该研究是朝向混合的[NR，N-222] /甲醇/水相中的温度驱动的可逆双相系统的设计，描述和优化的设计，描述和优化，起始从[NH4] [TF2N]高达[N-14，N-222] [TF2N]。在温度下，以及提供高转化率和光学产率的其他条件，反应混合物是单相的。在较低的温度下，由于其强的非极性特征，混合物成为具有长烷基链的离子液体的离子液体（即[N-14，N-222] [TF2N]）。形成的离子液相容纳细胞ru复合物，水/甲醇相对反应产物。反应后，当混合物冷却时，在离子液相中保持超过90％的催化复合物。还讨论了粘度和密度数据。似乎可逆的双相系统提供了一种促进手性ru-复合物与反应混合物分离的方法。由于复杂的处理条件的高灵敏度，其重用仍需要进一步优化。 （c）2019化学工程师机构。 elsevier b.v出版。保留所有权利。

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