Key Tertiary Interactions in FMN Riboswitch Aptamers Required for Ligand Binding

Rode Ambadas B.; Endoh Tamaki; Sugimoto Naoki

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Key Tertiary Interactions in FMN Riboswitch Aptamers Required for Ligand Binding

机译：配体结合所需的FMN核糖织波适体的关键三级相互作用

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The key tertiary interactions in the riboswitch aptamer that are critical for flavin mononucleotide binding were identified by structure-guided mutations. Binding affinity was reduced significantly (more than 16-fold) after disruption of non-canonical G. G base pair and enhanced moderately (up to 2.1-fold) after mutation in the base triple or T-loop like motif.

机译：通过结构引导突变鉴定对黄蛋白单核苷酸结合至关重要的核糖开关适体的关键三级相互作用。在基部三倍或T环突变之后，在非规范G.G碱基对中断后，在基部三倍或T环之后增强了突变后的结合亲和力（超过16倍）。

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《Bulletin of the Chemical Society of Japan》 |2015年第7期|共3页
作者
Rode Ambadas B.; Endoh Tamaki; Sugimoto Naoki;
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作者单位

Konan Univ Frontier Inst Biomol Engn Res Kobe Hyogo 6500047 Japan;

Konan Univ Frontier Inst Biomol Engn Res Kobe Hyogo 6500047 Japan;

Konan Univ Grad Sch Frontiers Innovat Res Sci &

Technol FIRS Kobe Hyogo 6500047 Japan;

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正文语种 eng
中图分类化学;
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1. Key Tertiary Interactions in FMN Riboswitch Aptamers Required for Ligand Binding [J] . Rode Ambadas B., Endoh Tamaki, Sugimoto Naoki Bulletin of the Chemical Society of Japan . 2015,第7期

机译：配体结合所需的FMN核糖织波适体的关键三级相互作用
2. Molecular sensing by the aptamer domain of the FMN riboswitch: a general model for ligand binding by conformational selection [J] . Estefanía Mondragón, Quentin Vicens, Robert T. Batey Nucleic acids research . 2011,第19期

机译：通过FMN核糖开关的适体结构域进行分子传感：通过构象选择进行配体结合的一般模型
3. Allosteric tertiary interactions preorganize the c-di-GMP riboswitch and accelerate ligand binding [J] . Wood S., Ferré-DAmaré A.R., Rueda D. ACS Chemical Biology . 2012,第5期

机译：变构三级相互作用可预先组织c-di-GMP核糖开关并加速配体结合
4. Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (40): Crowding Regulates the Riboswitch Aptamer-Ligand Recognition Mechanism in Bacterial Pathogenesis Mimic Condition [C] . Ambadas B. Rode, Tamaki Endoh, Naoki Sugimoto 日本化学会春季年会講演予稿集 . 2018

机译：核酸化学超出Watson-Crick双螺旋（40）：拥挤调节细菌性发病机制模拟条件的核糖开关适体 - 配体识别机制
5. Biochemical Investigation of the Mechanism of Cooperative Ligand Binding by the Glycine Riboswitch: Defining the Role of RNA Aptamer Tertiary Interactions Important for Cooperativity. [D] . Erion, Thanh Vu. 2011

机译：甘氨酸核糖开关合作配体结合机制的生化研究：定义对重要的RNA适体三级相互作用的作用。
6. Observation of long-range tertiary interactions during ligand binding by the TPP riboswitch aptamer [O] . Van K Duesterberg, Irena T Fischer-Hwang, Christian F Perez, 2015

机译：TPP核糖开关适体与配体结合期间的长距离三级相互作用的观察
7. Observation of long-range tertiary interactions during ligand binding by the TPP riboswitch aptamer [O] . Van K Duesterberg, Irena T Fischer-Hwang, Christian F Perez, 2015

机译：TPP Riboswitch适体的配体结合过程中远程三级相互作用的观察
8. Riboswitch-Mediated Aptamer Binding for Imaging and Therapy (RABIT): A Novel Technique to Selectively Target an Intracelluar Ligand Specific for Ovarian Cancer. [R] . Kolodny, G. M., Yisraeli, J. 2015

机译：用于成像和治疗的核糖开关介导的适体结合（RaBIT）：选择性靶向卵巢癌特异性细胞内配体的新技术。

Key Tertiary Interactions in FMN Riboswitch Aptamers Required for Ligand Binding

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