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首页> 外文期刊>Bulletin of the Chemical Society of Japan >Morphology Change from Nanotube to Vesicle and Monolayer/Bilayer Alteration by Amphiphilic Block Polypeptides Having Aromatic Groups at C Terminal
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Morphology Change from Nanotube to Vesicle and Monolayer/Bilayer Alteration by Amphiphilic Block Polypeptides Having Aromatic Groups at C Terminal

机译：通过在C终端具有芳族基团的两亲嵌段多肽从纳米管与囊泡和单层/双层/双层改变的形态变化

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摘要

Various amphiphilic block polypeptides having aromatic groups at the C terminal of a Leu-based hydrophobic helical block, poly(sarcosine)-b-(L-Leu-Aib)(6)-ethylcarbazole, poly(sarcosine)-b-(D-Leu-Aib)(6)-naphthalimide, and poly(sarcosine)-b-(D-Leu-Aib)(6)-porphyrin, were synthesized and self-assembled in water. Molecular assemblies of distorted sheet, saddle-like sheet, and micelle were identified, which were different from the curved sheet of poly(sarcosine)-b-(L-Leu-Aib)(6) without any aromatic groups, indicating that the attachment of the aromatic groups to the C terminal significantly influenced the morphology. Upon heating at 90 degrees C, vesicles were generated with the three amphiphilic polypeptides with aromatic groups as opposed to the nanotubes of poly(sarcosine)-b-(L-Leu-Aib)(6). The precise observations of these vesicles by AFM revealed formation of monolayer for poly(sarcosine)-b-(L-Leu-Aib)(6)-ethylcarbazole and bilayers for poly(sarcosine)-b-(D-Leu-Aib)(6)-naphthalimide and poly(sarcosine)-b-(D-Leu-Aib)(6)-porphyrin. Attachment of aromatic groups at the C terminal therefore influences morphology and monolayer/bilayer alteration in accordance with the type of aromatic groups.
机译：在Leu基疏水螺旋块的C末端具有芳族基团的各种两亲嵌段多肽，聚（Sarcosine）-b-（L-Leu-aib）（6） - 乙基咔唑，聚（Sarcosine）-B-（D- Leu-AIB）（6） - 萘酰亚胺，和聚（Sarcosine）-B-（D-Leu-aib）（6） - 孢子，在水中合成和自组装。鉴定了扭曲的片材，鞍状片和胶束的分子组件，其与弯曲的聚（Sarcosine）-b-（L-Leu-aib）（6）的弯曲片不同，没有任何芳族基团，表明附件芳族基团到C末端显着影响了形态。在加热时，在90℃下加热，用三个两亲多肽产生囊泡，与芳族基团相对，而不是聚（Sarcosine）-B-（L-Leu-aib）（6）的纳米管。通过AFM的这些囊泡的精确观察显示了聚（Sarcosine）-B-（L-Leu-AIB）（6） - 乙基咔唑和聚苯甲酰甲基（Sarcosine）-B-（D-Leu-Aib）的双层的形成（ 6） - 萘酰亚胺和聚（Sarcosine）-B-（D-Leu-aib）（6）-纯蛋白。因此，在C末端的芳族基团的附着根据芳族基团的类型影响形态和单层/双层改变。

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