Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells

Kong Lei; Rosli Nur Farhanah; Chia Hui Ling; Guan Jianguo; Pumera Martin

首页> 外文期刊>Bulletin of the Chemical Society of Japan >Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells

【24h】

Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells

机译：自推进的自主Mg / Pt Janus Microomotor与人细胞相互作用

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Magnesium (Mg)-based micromotors have attracted considerable attention as they are capable of moving in water and human blood plasma without external fuels. It has also been demonstrated that they have potential for drug delivery in mouse stomach. However, their biocompatibility and cytotoxicity to human cells have yet to be studied. Therefore, we performed cytotoxicity study of Mg/Pt Janus micromotors with human lung carcinoma epithelial cells (A549), human breast cancer cells (MCF-7), human embryonic kidney cells (HEK-293), human liver carcinoma cells (HepG2) and human cervical cancer cells (HeLa). The highest concentration of micromotors tested, 200 mu g mL(-1), drastically induced a high toxic effect on the cells and reduced the cell viability to below 60%. This shows while Pt/Au nanomachines were found to be safe previously, this is not the case of the Mg/Pt micromachines.

机译：基于镁（MG）的微电机吸引了相当大的关注，因为它们能够在没有外部燃料的情况下在水和人血浆中移动。还证明了他们在小鼠胃中具有药物递送的可能性。然而，尚未研究其对人细胞的生物相容性和细胞毒性。因此，我们对人肺癌上皮细胞（A549），人乳腺癌细胞（MCF-7），人胚胎肾细胞（Hep-293），人肝癌细胞（HepG2）和人宫颈癌细胞（Hela）。测试的最高浓度的浓度，200μgmm（-1），对细胞进行了大量诱导的高毒性作用，并将细胞活力降低至低于60％。此表明在发现Pt / Au纳米载体之前是安全的，这不是Mg / Pt微血的情况。

著录项

来源
《Bulletin of the Chemical Society of Japan》 |2019年第10期|共5页
作者
Kong Lei; Rosli Nur Farhanah; Chia Hui Ling; Guan Jianguo; Pumera Martin;
展开▼
作者单位

Nanyang Technol Univ Sch Phys &

Math Sci Div Chem &

Biol Chem Singapore 637371 Singapore;

Nanyang Technol Univ Sch Phys &

Math Sci Div Chem &

Biol Chem Singapore 637371 Singapore;

Nanyang Technol Univ Sch Phys &

Math Sci Div Chem &

Biol Chem Singapore 637371 Singapore;

Wuhan Univ Technol State Key Lab Adv Technol Mat Synth &

Proc Wuhan 430070 Hubei Peoples R China;

Nanyang Technol Univ Sch Phys &

Math Sci Div Chem &

Biol Chem Singapore 637371 Singapore;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词
Cytotoxicity; Micromotors; Human cells;

机译：细胞毒性;Microomotors;人体细胞;

相似文献

外文文献
中文文献
专利

1. Encryption/decryption and microtarget capturing by pH-driven Janus microstructures fabricated by the same femtosecond laser printing parameters [J] . Zhaoxin Lao, Rui Sun, Dongdong Jin, 极端制造（英文） . 2021,第002期
2. Role of Toll-like receptor 4 and Janus kinase and signal transducer and activator of transcription signal transduction pathway in sepsis-induced brain damage [J] . Haiyan Yin, Jianrui Wei, Rui Zhang, 中国神经再生研究（英文版） . 2011,第032期
3. Role of Toll-like receptor 4 and Janus kinase and signal transducer and activator of transcription signal transduction pathway in sepsis-induced brain damage [J] . Haiyan Yin, Jianrui Wei, Rui Zhang, 中国神经再生研究：英文版 . 2011,第032期
4. Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells [J] . Kong Lei, Rosli Nur Farhanah, Chia Hui Ling, Bulletin of the Chemical Society of Japan . 2019,第10期

机译：自推进的自主Mg / Pt Janus Microomotor与人细胞相互作用
5. Autonomous Motion and Temperature-Controlled Drug Delivery of Mg/Pt-Poly(N-isopropylacrylamide) Janus Micromotors Driven by Simulated Body Fluid and Blood Plasma [J] . Fangzhi Mou, Chuanrui Chen, Qiang Zhong ACS applied materials & interfaces . 2014,第12期

机译：模拟体液和血浆驱动的Mg / Pt-聚（N-异丙基丙烯酰胺）Janus微电机的自主运动和温度控制的药物输送
6. Janus kinases promote cell-surface expression and provoke autonomous signalling from routing-defective G-CSF receptors [J] . Albert W?lfler, Annemarie Meenhuis, Ivo?P. Touw, The biochemical journal . 2009,第3期

机译：Janus激酶促进细胞表面表达并从路由缺陷性G-CSF受体激发自主信号转导
7. Modeling of the knowledge-based 'intelligent system'-environment interaction: description application to human-machine interaction and system-theoretic aspects leading to a new type of autonomous systems [C] . Soeffker, D. . 2001

机译：基于知识的“智能系统”-环境交互的建模：描述在人机交互和系统理论方面的应用，从而导致一种新型的自治系统
8. Interactions between luteinizing hormone releasing hormone (LHRH), opioid receptors and estrogen in SK-N-SH human neuroblastoma cells. [D] . Bennett, Lunawati Lo. 2002

机译：黄体生成素释放激素（LHRH），阿片样物质受体和雌激素在SK-N-SH人成神经细胞瘤细胞中的相互作用。
9. Cell-Autonomous Defects in Thymic Epithelial Cells Disrupt Endothelial-Perivascular Cell Interactions in the Mouse Thymus [O] . Jerrod L. Bryson, Ann V. Griffith, Bernard Hughes III, -1

机译：胸腺上皮细胞中的细胞自主性缺陷破坏了小鼠胸腺中的内皮-血管周围细胞相互作用。
10. Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase [O] . Behrmann, Iris, Smyczek, Tanja, Heinrich, Peter C., 2004

机译：重新审查Janus激酶（Jak）亚细胞定位：通过细胞因子受体相互作用对内源性Janus激酶1的独家膜定位揭示了Jak.receptor复合物等同于受体酪氨酸激酶

Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells

摘要

著录项

相似文献

相关主题

期刊订阅