Cyanoethylation of substituted 4-azafluorenes. Synthesis of spiro-[4-azafluorene-9-cyclopentenes]

N. M. Mikhailova; A. N. Levov; S. V. Gozun; O. O. Timonina; F. Toze; A. V. Varlamov

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Cyanoethylation of substituted 4-azafluorenes. Synthesis of spiro-[4-azafluorene-9-cyclopentenes]

机译：取代的4-氮杂氟苯的氰基乙基化。螺纹合成[4-氮杂氟-9-环戊烯]

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Cyanoethylation of 9-phenacyl(β-hydroxy-β-phenylethyl-, or acetamido)-4-azafluorenes under conditions of the Michael reaction occurs regioselectively at position 9. 1-Amino-4-azafluorene under these conditions forms 1-[N,N-di-(β-cyanoethyl)amino)]-(9-β-cyanoethyl)-4-azafluorene. The cyclization of 9-(β-cyanoethyl)-9-phenacyl-4-azafluorene has been carried out into 1′-cyano-2′-phenylspiro[4-aza-fluorene-9,4′-cyclopentene and 1′-imino-2′-hydroxybenzylidenespiro[4-azafluorene-9.3′-cyclopentane]-substituted in the five-membered fragment.

机译：在迈克尔反应的条件下，在迈克尔反应条件下氰基甲基化（β-羟基-β-苯乙基 - 或乙酰氨基）-4-氮杂氟苯在这些条件下，1-氨基-4-二氟烯形成1- [n， N-二（β-氰基乙基）氨基）] - （9-β-氰基乙基）-4-氮杂芳烃。已经将9-（β-氰基乙基）-9-苯基-4-二氟烯的环化已进行成1'-氰基-2'-苯基苯胺[4-亚沙芴-9,4'-环戊烯和1'-咪喹 -2'-羟基苄基键基 - 在五元片段中 - 二取代物中取出。

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来源
《Chemistry of heterocyclic compounds》 |2006年第10期|共5页
作者
N. M. Mikhailova; A. N. Levov; S. V. Gozun; O. O. Timonina; F. Toze; A. V. Varlamov;
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作者单位

Russian People’s Friendship Moscow 117198;

Russian People’s Friendship Moscow 117198;

Russian People’s Friendship Moscow 117198;

Russian People’s Friendship Moscow 117198;

Russian People’s Friendship Moscow 117198;

Russian People’s Friendship Moscow 117198;

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原文格式 PDF
正文语种 eng
中图分类杂环化合物;
关键词
azafluorene; spiroazafluorenecyclopentane; spiroazafluorene-cyclopentene; intramolecular cyclization; cyanoethylation;

机译：氮杂氟;螺氮杂氟氯化萘醌;螺氟芴 - 环戊烯;分子分子化;氰基甲基化;

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1. Cyanoethylation of substituted 4-azafluorenes. Synthesis of spiro-[4-azafluorene-9-cyclopentenes] [J] . N. M. Mikhailova, A. N. Levov, S. V. Gozun, Chemistry of heterocyclic compounds . 2006,第10期

机译：取代的4-氮杂氟苯的氰基乙基化。螺纹合成[4-氮杂氟-9-环戊烯]
2. Synthesis and biological activities of novel 2-(5'-substituted-3'-phenylindole-2'-yl)-l,3,4-oxadiazino[5,-b]]indole and 3-(5'-substituted-3'-phenylindole-2'-amido)spiro-(indol-3",2-thiazolidine)-2",4-diones [J] . J S Biradar, S Y Manjunath Indian Journal of Chemistry, Section B. Organic Including Medicinal . 2004,第2期

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3. Synthesis of novel trifluoromethyl-substituted spiro-[chromeno[4,3-d]pyrimidine-5,1 '-cycloalkanes], and evaluation of their analgesic effects in a mouse pain model [J] . Bonacorso Helio G., Rosa Wilian C., Oliveira Sara M., Bioorganic and Medicinal Chemistry Letters . 2017,第7期

机译：新型三氟甲基取代的螺孢素[Chromeno [4,3-D]嘧啶-5,1' - 环烷烃]的合成，评价鼠标疼痛模型中的镇痛作用
4. A study of electrical double-layer characteristic of activated carbon electrode in spiro-(l, 1')-bipyrrolidinium tetrafluoroborate elecrtolyte [C] . XuewenYu, Zhiqiang Shi, Jing Wang Annual World Conference on Carbon . 2014

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5. I. Synthesis of substituted naphthalenes utilizing active nickel. II. Synthesis of substituted naphthoquinones and formation of a charge transfer complex. III. Synthesis of substituted 1,4-diphenyl-2-butenes from (eta(6):eta(6)-1,4-diphenyl-1,3-butadiene)-bis(tricarbonylchromium) [D] . Forkner, Matthew W. 1988

机译：I.利用活性镍合成取代的萘。二。取代萘醌的合成和电荷转移配合物的形成。三，由（eta（6）：eta（6）-1,4-二苯基-1,3-丁二烯）-双（三羰基铬）合成取代的1,4-二苯基-2-丁烯
6. Cyanoethylation of the glucans dextran and pullulan: Substitution pattern and formation of nanostructures and entrapment of magnetic nanoparticles [O] . Kathrin Fiege, Heinrich Lünsdorf, Sevil Atarijabarzadeh, 2012

机译：葡聚糖葡聚糖和支链淀粉的氰乙基化：取代模式和纳米结构的形成以及磁性纳米颗粒的捕获
7. Synthesis and Antiarrhythmic Activity of 2,2-Dialkyl-1'-(N-substituted aminoalkyl)-spiro-(chroman-4,4'-imidazolidine)-2',5'-diones. [O] . Masayuki MATSUKURA, Yoshiharu DAIKU, Kouichirou UEDA, 1992

机译：2,2-二烷基-1' - （N-取代的氨基烷基） - 苯甲酰基（Chroman-4,4'-咪唑烷）-2'，5'-致硫醚的合成和抗心律失常活性。

Cyanoethylation of substituted 4-azafluorenes. Synthesis of spiro-[4-azafluorene-9-cyclopentenes]

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