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首页> 外文期刊>ChemPlusChem >Enantioselective Sulfoxidation of Thioanisole by Cascading a Choline Oxidase and a Peroxygenase in the Presence of Natural Deep Eutectic Solvents
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Enantioselective Sulfoxidation of Thioanisole by Cascading a Choline Oxidase and a Peroxygenase in the Presence of Natural Deep Eutectic Solvents

机译：通过级联胆碱氧化酶及其在天然深的共晶溶剂存在下通过胆碱氧化酶和过氧酶映对硫氧化

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摘要

Abstract A bienzymatic cascade for selective sulfoxidation is presented. The evolved recombinant peroxygenase from Agrocybe aegeritra catalyses the enantioselective sulfoxidation of thioanisole whereas the choline oxidase from Arthrobacter nicotianae provides the H 2 O 2 necessary via reductive activation of ambient oxygen. The reactions are performed in choline chloride‐based deep eutectic solvents serving as co‐solvent and stoichiometric reductant at the same time. Very promising product concentrations (up to 15?mM enantiopure sulfoxide) and catalyst performances (turnover numbers of 150,000 and 2100 for the peroxygenase and oxidase, respectively) have been achieved.
机译：摘要提出了一种选择性亚磺氧化的酶级联。 来自Agrocybe Aegeritra的进化重组过氧基因催化剂催化硫代唑的映选择性亚磺氧化，而来自Arthrobacter的胆碱氧化酶提供通过环形氧的还原活化的H 2 O 2。 反应在氯化胆碱基的基于氯化胆碱基的深共晶溶剂中，同时用作共溶剂和化学计量还原剂。 已经实现了非常有前途的产品浓度（最多15？mm对硫氧化硫醚）和催化剂性能（分别为150,000和2100的过氧酶和氧化酶的周转数）。

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  • 来源
    《ChemPlusChem》 |2020年第1期|共4页
  • 作者

    Li Yongru; Ma Yunjian; Li Peilin; Zhang Xizhen; Ribitsch Doris; Alcalde Miguel; Hollmann Frank; Wang Yonghua;

  • 作者单位

    School of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510640 P. R;

    School of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510640 P. R;

    School of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510640 P. R;

    School of Biology and Biological EngineeringSouth China University of TechnologyGuangzhou 510640 P;

    Austrian Centre for Industrial Biotechnology (ACIB)Konrad Lorenz Stra?e 22 3430 Tulln Austria;

    Department of BiocatalysisInstitute of Catalysis CSIC28049 Madrid Spain;

    Department of BiotechnologyDelft University of TechnologyVan der Maasweg 9 2629HZ Delft (The;

    School of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510640 P. R;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

    biocatalysis; enantioselectivity; natural deep eutectic solvents; peroxygenases; sulfoxidation;

    机译：生物分析;对映选择性;天然深凝胶溶剂;过氧基团;亚磺氧化;

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