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首页> 外文期刊>ChemPlusChem >Synthesis of light-induced expandable photoresponsive polymeric nanoparticles for triggered release
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Synthesis of light-induced expandable photoresponsive polymeric nanoparticles for triggered release

机译：用于触发释放的光诱导的膨胀光学光学聚合物纳米粒子的合成

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摘要

High stability of drug-delivery nanocarriers during blood circulation is critical for effective drug delivery and low systematic toxicity, although destabilization of these nanocarriers is required for efficient release when they reach target sites. To develop efficient polymeric nanocarriers, we intended to synthesize and characterize a group of cross-linked, light-induced, expandable, polymeric nanoparticles through miniemulsion polymerization. These synthesized nanoparticles were stable in aqueous solutions, although light irradiation led to particle uncaging and further particle expansion up to 315-fold in volume. This resulted in the efficient release of the encapsulated contents in aqueous solutions and three cell lines (HeLa, RAW264.7, and MCF-7). Selective triggered release was also successfully achieved with spatial resolution in cell monolayers. In addition, curcumin encapsulation and photoregulation of its release were realized. Further cell viability of encapsulated curcumin was successfully achieved with light activation. Open the cage: A series of cross-linked photolabile polymeric nanoparticles are described. Light irradiation leads to the particle swelling 315-fold in volume and the efficient release of the encapsulated contents in both aqueous solutions and cells. Selective triggered release on a cell monolayer is achieved. Curcumin is efficiently encapsulated in particles and photoregulation of its release and cell viability is also successfully achieved.
机译：血液循环期间药物递送纳米载体的高稳定性对于有效的药物递送和低系统毒性至关重要，尽管当它们到达靶位点时需要有效释放所需的这些纳米载体的稳定化。为了开发高效的聚合物纳米载体，我们旨在通过微乳液聚合来合成和表征一组交联的，光诱导的，可膨胀的聚合物纳米颗粒。这些合成的纳米颗粒在水溶液中稳定，尽管光照射导致颗粒未分散和进一步的颗粒膨胀，其体积高达315倍。这导致在水溶液中有效释放包封的内容物和三种细胞系（Hela，Raw264.7和MCF-7）。在细胞单层中的空间分辨率也成功地实现了选择性触发释放。此外，实现了姜黄素的包封和其释放的光调节。通过光活化成功地实现了包封姜黄素的进一步细胞活力。打开笼子：描述了一系列交联光塑料聚合物纳米颗粒。光照射导致体积315倍的颗粒溶胀，并且在水溶液和细胞中有效释放包封的内容物。达到细胞单层上的选择性触发释放。姜黄素有效地包封在颗粒中，并且还成功地实现了其释放的光探测和细胞活力。

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  • 来源
    《ChemPlusChem》 |2013年第10期|共9页
  • 作者

    WangZ.; WangP.; TangX.;

  • 作者单位

    State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking;

    State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking;

    State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

    curcumins; drug delivery; encapsulation; nanoparticles; photochemistry;

    机译：姜黄素;药物递送;封装;纳米粒子;光化学;

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