Can Tolvaptan Protect Renal Function in the Early Postoperative Period of Cardiac Surgery? - Results of a Single-Center Randomized Controlled Study -

Kishimoto Yuichiro; Nakamura Yoshinobu; Harada Shingo; Onohara Takeshi; Kishimoto Satoru; Kurashiki Tomohiro; Fujiwara Yoshikazu; Nishimura Motonobu

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Can Tolvaptan Protect Renal Function in the Early Postoperative Period of Cardiac Surgery? - Results of a Single-Center Randomized Controlled Study -

机译：托洛瓦班可以在心脏病术后早期保护肾功能吗？ - 单中心随机对照研究的结果 -

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Background: Oral administration of tolvaptan, a vasopressin V-2 receptor antagonist, significantly reduces deterioration of renal function, which has recently been highlighted as an exacerbating factor for adverse events in patients with acute heart failure. In the present study we tested the hypothesis that concomitant administration of tolvaptan with a conventional diuretic is beneficial for perioperative body fluid management in patients who have undergone cardiac surgery.

机译：背景：罗瓦膜素V-2受体拮抗剂的口服施用显着降低了肾功能的恶化，这最近被突出为急性心力衰竭患者不良事件的加剧因素。在本研究中，我们测试了一种假设，即伴随着常规利尿剂的罗瓦膜施用对患者的围手术期体液管理有利于心脏手术。

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来源
《Circulation journal》 |2018年第4期|共9页
作者
Kishimoto Yuichiro; Nakamura Yoshinobu; Harada Shingo; Onohara Takeshi; Kishimoto Satoru; Kurashiki Tomohiro; Fujiwara Yoshikazu; Nishimura Motonobu;
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作者单位

Tottori Univ Fac Med Dept Cardiovasc Surg Yonago Tottori Japan;

Tottori Univ Fac Med Dept Cardiovasc Surg Yonago Tottori Japan;

Tottori Univ Fac Med Dept Cardiovasc Surg Yonago Tottori Japan;

Tottori Univ Fac Med Dept Cardiovasc Surg Yonago Tottori Japan;

Tottori Univ Fac Med Dept Cardiovasc Surg Yonago Tottori Japan;

Tottori Univ Fac Med Dept Cardiovasc Surg Yonago Tottori Japan;

Tottori Univ Fac Med Dept Cardiovasc Surg Yonago Tottori Japan;

Tottori Univ Fac Med Dept Cardiovasc Surg Yonago Tottori Japan;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Cardiac surgery; Diuretics; Renal function;

机译：心脏手术;利尿剂;肾功能;

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专利

1. Can Tolvaptan Protect Renal Function in the Early Postoperative Period of Cardiac Surgery?　― Results of a Single-Center Randomized Controlled Study ― [J] . Yuichiro Kishimoto, Yoshinobu Nakamura, Shingo Harada, Circulation journal . 2018,第4期

机译：托伐普坦能否在心脏外科手术后早期保护肾脏功能？ ―单中心随机对照研究的结果―
2. Ciclosporin to Protect Renal function In Cardiac Surgery (CiPRICS): a study protocol for a double-blind, randomised, placebo-controlled, proof-of-concept study [J] . Lars Algotsson, Eskil Elmér, Edgars Grins, BMJ Open . 2016,第12期

机译：环孢素在心脏外科手术中保护肾脏功能（CiPRICS）：一项双盲，随机，安慰剂对照，概念验证研究的研究方案
3. Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trial. [J] . Singla N, Warltier DC, Gandhi SD, Anesthesia and Analgesia: Journal of the International Anesthesia Research Society . 2008,第1期

机译：心脏外科手术患者的急性术后高血压的治疗：氯维地平评估其在心脏外科手术2（ESCAPE-2）中的术后降压作用的功效研究，这是一项随机，双盲，安慰剂对照试验。
4. The Efficacy of Preoperative Versus Postoperative Rofecoxib for Preventing Acute Postoperative Dental Pain: A Randomized Cross-over Study Using Bilateral Oral Surgery [C] . K.S. Ong, R.A. Seymour, J.F. Yeo, International Pain Clinic . 2004

机译：术前与术后ROFecoxib用于预防急性术后牙科疼痛的疗效：使用双侧口腔手术进行随机交叉研究
5. Image-Analysis with Fiji Program on Peripheral Blood Monocular Cells After Consumption of High-Fat, High Carbohydrate Meal with or Without Addition of Spices: A Single-Center Randomized, Blinded, Placebo-Controlled, 4-Arm, 24-hr Acute Crossover Study [D] . Tsai, Meng Fu. 2020

机译：用斐济单眼细胞进行斐济血液单眼细胞的图像分析，用或没有添加香料：单中心随机，盲，安慰剂控制，4臂，24小时急性交叉研究
6. Ciclosporin to Protect Renal function In Cardiac Surgery (CiPRICS): a study protocol for a double-blind randomised placebo-controlled proof-of-concept study [O] . Per Ederoth, Edgars Grins, Alain Dardashti, 2016

机译：环孢素在心脏外科手术中保护肾脏功能（CiPRICS）：一项双盲随机安慰剂对照概念验证研究的研究方案
7. Can Tolvaptan Protect Renal Function in the Early Postoperative Period of Cardiac Surgery? ― Results of a Single-Center Randomized Controlled Study ― [O] . Yuichiro Kishimoto, Yoshinobu Nakamura, Shingo Harada, 2018

机译：托洛瓦班可以在心脏病术后早期保护肾功能吗？ - 单中心随机对照研究的结果 -

Can Tolvaptan Protect Renal Function in the Early Postoperative Period of Cardiac Surgery? - Results of a Single-Center Randomized Controlled Study -

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