Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study

Toraih Eman A.; Alrefai Hani G.; Hussein Mohammad H.; Helal Ghada M.; Khashana Moataz S.; Fawzy Manal S.

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Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study

机译：HCV诱导肝细胞癌外部线粒体膜TOM34的热休克蛋白HSP90AA1和译团的过度表达及译团：试验研究

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Objective: Identification of new molecular markers to enhance early diagnosis, prognosis and/or treatment of hepatocellular carcinoma (HCC) is a need. TOM34 (34 kDa-translocase of the outer mitochondrial membrane) protein expression deregulation has demonstrated to be involved in the growth of many cancers. Here, we aimed at evaluating serum TOM34 and some heat shock proteins (HSPA4, HSPA1B, and HSP90AA1) expressions in hepatitis C virus (HCV)-related cirrhosis and HCV-induced HCC relative to controls and correlating these expressions to the clinicopathological data.

机译：目的：鉴定新的分子标记，以增强早期诊断，预后和治疗肝细胞癌（HCC）是一种需要。 Tom34（外部线粒体膜的34 kda译）蛋白表达放松调节已经证明涉及许多癌症的生长。在此，我们旨在评估血清Tom34和一些热休克蛋白（HSPA4，HSPA1b和Hsp90AA1）的表达，相对于对照，并将这些表达与临床病理数据相关联。

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来源
《Clinical Biochemistry》 |2019年第2019期|共8页
作者
Toraih Eman A.; Alrefai Hani G.; Hussein Mohammad H.; Helal Ghada M.; Khashana Moataz S.; Fawzy Manal S.;
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作者单位

Suez Canal Univ Fac Med Dept Histol &

Cell Biol Genet Unit Ismailia 41522 Egypt;

Mansoura Univ Fac Med Dept Med Biochem Mansoura Egypt;

Minist Hlth &

populat Cairo Egypt;

Mansoura Univ Fac Med Dept Med Biochem Mansoura Egypt;

Suez Canal Univ Fac Med Ismailia Egypt;

Northern Border Univ Fac Med Dept Biochem Ar Ar Saudi Arabia;

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原文格式 PDF
正文语种 eng
中图分类诊断学;
关键词
Hepatocellular Carcinoma; TOM34; HSPA4; HSPA1B; HSP9OAA1; Real-Time Polymerase Chain Reaction;

机译：肝细胞癌;TOM34;HSPA4;HSPA1B;HSP9OAA1;实时聚合酶链反应;

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1. Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study [J] . Toraih Eman A., Alrefai Hani G., Hussein Mohammad H., Clinical Biochemistry . 2019,第期

机译：HCV诱导肝细胞癌外部线粒体膜TOM34的热休克蛋白HSP90AA1和译团的过度表达及译团：试验研究
2. Expression, purification, and in vitro characterization of the human outer mitochondrial membrane receptor human translocase of the outer mitochondrial membrane 20. [J] . Schleiff E, Orlicky S, Vrielink A, Archives of Biochemistry and Biophysics . 1999,第1期

机译：人体外线粒体膜受体20的表达，纯化和体外表征
3. Clueless is a conserved ribonucleoprotein that binds the ribosome at the mitochondrial outer membrane Clueless is a conserved ribonucleoprotein that binds the ribosome at the mitochondrial outer membrane Clueless is a conserved ribonucleoprotein that binds the ribosome at the mitochondrial outer membrane [J] . Rachel T. Cox, Aditya Sen Biology Open . 2016,第2期

机译：无能为力的是一种保守的核糖核酸蛋白，与线粒体外膜的核糖体结合。无能为力的是一种保守的核糖核蛋白，其与线粒体外膜的核糖体结合
4. Study on the Anti-tumor Mechanisms of Heat Shock Protein 72/alpha-fetoprotein Epitope Peptide Complex Against Hepatocellular Carcinoma Cell Hepal-6 [C] . Bing Xu, Xiaoping Wang, Huanping Lin International Symposium on Application of Materials Science and Energy Materials . 2019

机译：热休克蛋白72 /α-胎儿表位肽复合物对肝细胞癌细胞肝癌的抗肿瘤机制研究
5. The Functional Characterization of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone in Hepatocellular Carcinoma: Targeting Heat Shock Protein 27 to Mediate Mitochondrial Apoptosis. [D] . Fu, Weiming. 2012

机译：1,3,5-三羟基-13,13-二甲基-2H-吡喃[7,6-b]蒽酮在肝细胞癌中的功能表征：靶向热休克蛋白27介导线粒体细胞凋亡。
6. Interactions of Mitochondrial Presequence Peptides with the Mitochondrial Outer Membrane Preprotein Translocase TOM [O] . Mercedes Romero-Ruiz, Kozhinjampara R. Mahendran, Reiner Eckert, 2010

机译：线粒体前肽与线粒体外膜前蛋白转运酶TOM的相互作用
7. Stoichiometry and thermodynamics of the interaction between the C-terminus of human 90kDa heat shock protein Hsp90 and the mitochondrial translocase of outer membrane Tom70 [O] . Gava Lisandra M., Gonçalves Danieli C., Borges Júlio C., 2011

机译：人类90kDa热休克蛋白Hsp90 C端与外膜Tom70线粒体转位酶相互作用的化学计量和热力学

Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study

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