Metformin in Gynecologic Cancers: Opening a New Window for Prevention and Treatment?

Madariaga Ainhoa; Goodwin Pamela J.; Oza Amit M.

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Metformin in Gynecologic Cancers: Opening a New Window for Prevention and Treatment?

机译：二甲双胍在妇科癌症中：打开一个用于预防和治疗的新窗口？

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Metformin is an affordable and well-tolerated drug used in type 2 diabetes. Potential anticancer effects of metformin in gynecologic malignancies include inhibition of the PI3K-mTOR pathway, hormone receptor regulation, and reduction of fibrosis and inflammation. Multiple studies are currently assessing its role in cancer prevention and as a treatment enhancer.

机译：二甲双胍是一种实惠且耐受良好的药物，用于2型糖尿病。二甲双胍在妇科恶性肿瘤中的潜在抗癌效应包括抑制PI3K-MTOR途径，激素受体调控和纤维化和炎症的降低。多项研究目前正在评估其在癌症预防中的作用和治疗增强剂。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2020年第3期|共3页
作者
Madariaga Ainhoa; Goodwin Pamela J.; Oza Amit M.;
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作者单位

Princess Margaret Canc Ctr Bras Family Drug Dev Program Div Med Oncol &

Hematol Toronto ON;

Mt Sinai Hosp Div Med Oncol Toronto ON Canada;

Princess Margaret Canc Ctr Bras Family Drug Dev Program Div Med Oncol &

Hematol Toronto ON;

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正文语种 eng
中图分类肿瘤学;
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1. Metformin in Gynecologic Cancers: Opening a New Window for Prevention and Treatment? [J] . Madariaga Ainhoa, Goodwin Pamela J., Oza Amit M. Clinical cancer research: an official journal of the American Association for Cancer Research . 2020,第3期

机译：二甲双胍在妇科癌症中：打开一个用于预防和治疗的新窗口？
2. Effects of extracts and molecules derived from medicinal plants of West Africa in the prevention and treatment of gynecological cancers. A Review [J] . Bagora Bayala, Abdou Azaque Zouré, Théodora M Zohoncon, American Journal of Cancer Research . 2020,第9期

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3. The Potential Role of Medicinal Mushrooms in the Prevention and Treatment of Gynecological Cancers: A Review [J] . Venturella Giuseppe, Saporita Paola, Gargano Maria Letizia International Journal of Medicinal Mushrooms . 2019,第3期

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4. Dose Calculation in Gynecological Brachytherapy using Monte Carlo simulation for intracavitary treatment of Cervical Cancer [C] . O.J. Garcia Contreras, F. Cristancho World Congress on Medical Physics and Biomedical Engineering . 2015

机译：蒙特卡罗仿真术治疗颈椎治疗宫颈癌的妇科近距离放射治疗剂量计算
5. From 'sex toy' to intrusive imposition: A qualitative examination of women's experiences with vaginal dilator use following treatment for gynecological cancer. [D] . Cullen, Kimberley-Anne S. 2011

机译：从“性玩具”到强加性行为：对妇科癌症治疗后妇女使用阴道扩张器的经历进行定性检查。
6. Chemotherapy-induced neurotoxicity in the treatment of gynecological cancers: State of art and an innovative approach for prevention [O] . Ester Oneda, Chiara Abeni, Laura Zanotti, 2021

机译：化疗诱导的神经毒性治疗妇科癌症：艺术状态和预防创新方法
7. Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment [O] . Wen Yue, Chung S. Yang, Robert S. DiPaola, 2014

机译：靶向AMPK-mTOR和胰腺癌预防治疗炎症的重新计算二甲双胍和阿司匹林

Metformin in Gynecologic Cancers: Opening a New Window for Prevention and Treatment?

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