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首页> 外文期刊>Clinical transplantation. >Age alone is not a contraindication to kidney donation: Outcomes of donor nephrectomy in the elderly
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Age alone is not a contraindication to kidney donation: Outcomes of donor nephrectomy in the elderly

机译：仅限年龄不是肾脏捐赠的禁忌：老年人供体肾切除术的结果

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With increasing organ demand, living kidney donation from older donors (60-years-old) has become more common. Between 1975 and 2014, 3752 donor nephrectomies (DN) were performed at University of Minnesota; 167 (4.5%) were 60-years-old Short- and long-term outcomes were compared between contemporaneous 60-years-old and 60-years-old donors. On univariate analysis, 60-years-old were more likely to have had prior abdominal surgery and hypertension; and less likely to smoke. Baseline estimated glomerular filtration rate (eGFR) was lower in 60-years-old (80 +/- 16 vs 101 +/- 26 mL/min/1.73 m(2); P .001). Intraoperative and postoperative complications were similar, except a higher prevalence of 30 day ileus (3% vs 7%; P = .021) and longer postoperative length of stay (LOS) (4.2 vs 4.6 days; P = .005). On multivariate analysis, 30 day ileus and LOS continued to be significantly greater for 60-years-old After 20 years post-DN, systolic blood pressure was significantly higher among 60-years-old (142 vs 125 mm Hg; P .001) and HTN was diagnosed earlier (9 vs 14 years). After donation, eGFR was significantly lower for 60-years-old but slope of eGFR and rates of end-stage renal disease (ESRD) were not significantly different 20 years post-DN. Thus, kidney donation among carefully selected 60-years-old poses minimal perioperative risks and no added risk of long-term ESRD.
机译：随着器官需求的增加，较老捐赠者的肾脏捐赠（＆ 60岁）变得更加常见。 1975年至2014年间，在明尼苏达大学进行3752名供体肾切除术（DN）; 167（4.5％）均为＆在同期＆gt之间比较了60岁的短期和长期结果; 60岁，60岁的捐助者。关于单变量分析，＆ 60岁更容易发生腹部手术和高血压;而且可能吸烟。基线估计的肾小球过滤速率（EGFR）较低，＆ 60岁（80 +/- 16 vs 101 +/- 26ml / min / 1.73 m（2）; p＆ .001）。除术中和术后并发症类似，除了＆ 30天的患者患病率较高（3％vs 7％; p = .021），术后长度延长（LOS）（4.2 Vs 4.6天; P = .005）。在多变量分析中，＆ 30天inleus和los持续更大，对于60岁以后，＆ 20年后的DN后，收缩压在60岁以下（142 vs） 125 mm Hg; p＆ .001）和早期诊断出来（9 vs 14年）。捐赠后，EGFR对于＆gt显着降低; 60岁但EGFR的坡度和末期肾病（ESRD）的率并没有显着不同，而且PTN后20年。因此，肾脏捐赠仔细选择，GT; 60岁的围绕围手术势风险，并且没有增加长期ESRD的风险。

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