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首页> 外文期刊>Clinical rheumatology >Synergism between apolipoprotein E AE4 allele and paraoxonase (PON1) 55-M allele is associated with risk of systemic lupus erythematosus
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Synergism between apolipoprotein E AE4 allele and paraoxonase (PON1) 55-M allele is associated with risk of systemic lupus erythematosus

机译：脂蛋白E AE4等位基因和律酶（PON1）55-m等位基因之间的协同作用与系统性红斑狼疮的风险有关

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摘要

Evidences indicate that abnormal lipid metabolism and lipid peroxidation can affect the progression of complications in systemic lupus erythematosus (SLE) patients. Apolipoprotein E (ApoE) and paraoxonase-1 (PON1) play important role in lipid metabolism and protection of lipid peroxidation. The polymorphisms of ApoE and paraoxonase (PON1) L55M (Met Leu) allele genes lead to disorders in lipid metabolism and are related to atherosclerosis. This study is the first investigation to examine the possible association between ApoE and PON1-L55M polymorphisms and correlation with serum arylesterase (ARE) activities of PON, levels of malondialdehyde (MDA), neopterin, and lipid lipoprotein in SLE patients from Iranian western population. The present case-control study consisted of 107 SLE patients and 101 gender- and age-matched, unrelated, healthy controls from Iran's western population. The ApoE and PON1-L55M genotypes were identified using PCR-RFLP method. The serum level of MDA, neopterin, lipid levels, and ARE activity were determined by HPLC, commercial kits, and spectrophotometry, respectively. Our results showed that ApoE epsilon 4 and PON1-55M alleles act synergistically to increase the risk of SLE by 1.47 times (p = 0.038). We found that the frequency of ApoE AE3/AE4 genotype was higher in SLE patients (11.2%) compared with control subjects (5%), although the difference was not significant (p = 0.087). This study for the first time not only demonstrates that ApoE AE4 and PON-55M alleles synergistically increase the risk of SLE but also reveals that serum levels of MDA, neopterin, and LDL-C are high in SLE patients. This information may be in value for evaluating SLE progression and in the elucidation of the mechanisms of the disease pathogenesis.
机译：证据表明，异常的脂质代谢和脂质过氧化会影响系统性狼疮红斑（SLE）患者的并发症的进展。载脂蛋白E（ApoE）和律催选酶-1（PON1）在脂质代谢和脂质过氧化的保护中起重要作用。 Apoe和律酶（PON1）L55M（MET＆LT; LEU）等位基因基因的多态性导致脂质代谢的病症，与动脉粥样硬化有关。本研究是第一次研究伊延伊朗西部人群的SLE患者PON，丙氨酸芳基酯酶（MDA），NeOpterin和脂质脂蛋白的血清芳基酯酶（IS）活性与血清芳基酯酶（AS）活性之间的相关性的研究。目前案例对照研究由107名SLE患者和101名性别和年龄匹配，无关，来自伊朗西部人口的不相关的健康控制。使用PCR-RFLP方法鉴定ApoE和PON1-L55M基因型。通过HPLC，商业试剂盒和分光光度法测定MDA，NeOpterin，脂肪水平的血清水平，以及活性。我们的研究结果表明，Apoe Epsilon 4和PON1-55M等位基因协同作用，以增加SLE的风险1.47次（P = 0.038）。我们发现，与对照组（5％）相比，SLE患者的ApoE AE3 / AE4基因型的频率高（11.2％），尽管差异不显着（p = 0.087）。本研究首次证明Apoe AE4和PON-55M等位基因协同增加了SLE的风险，但也表明SLE患者的MDA，NeOPETIN和LDL-C血清水平高。该信息可以是评估SLE进展的价值，并阐明疾病发病机制的机制。

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