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首页> 外文期刊>Clinical rheumatology >Central nervous system involvement in patients with antineutrophil cytoplasmic antibody-associated vasculitis: a study of 29 cases in a single Chinese center
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Central nervous system involvement in patients with antineutrophil cytoplasmic antibody-associated vasculitis: a study of 29 cases in a single Chinese center

机译：中枢神经系统参与患有抗嗜斗培养型细胞质抗体相关血管炎的患者：一项中国中心29例研究

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Background In antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), central nervous system (CNS) involvement is relatively uncommon. The current study retrospectively investigated the clinical features and outcomes of AAV patients with CNS involvement. Methods A total of 497 AAV patients were retrospectively recruited in our center, twenty-nine of which had CNS involvement. Clinical and radiological manifestations and the outcomes of these patients were analyzed. Results The predominant symptom was sensorimotor impairment. According to the MRI findings, twenty-four patients had cerebral ischemic lesions, four patients had hemorrhagic lesions, and one patient had pituitary mass. With a median follow-up of 25 (range 9-45) months, 23 of 24 patients with cerebral ischemic lesions responded to induction therapy, and symptoms were ameliorated. The remaining one died from acute myocardial infarction 2 months after the diagnosis of cerebral ischemic lesions. Compared with patients without CNS involvement, patients with CNS involvement had significantly higher level of Birmingham Vasculitis Activity Score (23.5 +/- 5.3 versus 18.8 +/- 6.5, P < 0.01) and significantly higher proportion of peripheral nervous system involvement (58.6% versus 14.6%, P < 0.01). However, we did not found significant difference of patients' survival between those with and without CNS involvement. Conclusion CNS involvement in Chinese patients with AAV was mainly manifested as cerebral ischemic lesions. Compared with patients without CNS involvement, patients with CNS involvement had a significantly more active disease of AAV, and significantly higher proportion of peripheral nervous system involvement.
机译：背景技术在抗嗜酸性培养基细胞质抗体（ANCA） - 分配血管炎（AAV），中枢神经系统（CNS）的参与相对罕见。目前的研究回顾性地研究了CNS参与的AAV患者的临床特征和结果。方法在我们的中心回顾性招募了497名AAV患者，其中二十九个有CNS参与。分析了临床和放射性表现和这些患者的结果。结果主要的症状是传感器障碍。根据MRI调查结果，二十四名患者患有脑缺血性病变，4名患者出血病变，一名患者患有垂体质量。在25（范围9-45）个月的中位随访，24例脑缺血性病变的23例反应诱导治疗，并且改善了症状。剩下的遗传从脑缺血性病变诊断后2个月死于急性心肌梗死。与没有CNS受累的患者相比，CNS受累的患者患者患者患者较高水平较高水平的伯明翰血管炎活动评分（23.5 +/- 5.3，P <0.01），外周神经系统的比例显着增加（58.6％与14.6％，P <0.01）。然而，我们没有发现患者在有和没有CNS参与之间的患者生存的显着差异。结论CNS参与中国AAV患者主要表现为脑缺血性病变。与没有CNS受累的患者相比，CNS受累的患者具有显着更具活跃的AAV疾病，并且具有明显更高的外周神经系统受累。

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