Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice.

Park E; Hwang I; Song JY; Jee Y

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Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice.

机译：人参的酸性多糖可抵抗小鼠全身γ射线对小肠造成的损害。

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An acidic polysaccharide of Panax ginseng (APG), ginsan, has been reported to protect the hematopoietic system by increasing the number of bone marrow cells and spleen cells. Therefore, we evaluated the ability of APG to protect mice from radiation-induced damage of the small intestine. APG treatment caused the lengthening of villi and a numerical increase of crypt cells in the small intestine at 3.5 days after 7Gy irradiation compared to irradiated, non-treated controls. In addition, APG significantly inhibited irradiation-induced apoptosis by decreasing the amount of pro-apoptotic p53 and Bax as well as augmenting that of anti-apoptotic Bcl-2 at 24h after irradiation. These results indicate that APG might be a useful adjunct to therapeutic irradiation as a protective agent for the gastrointestinal tract of cancer patients.

机译：据报道，人参的一种酸性多糖，即人参，可以通过增加骨髓细胞和脾细胞的数量来保护造血系统。因此，我们评估了APG保护小鼠免受辐射引起的小肠损害的能力。与未辐照的对照组相比，在7Gy辐照后3.5天，APG处理导致绒毛变长，小肠中的隐窝细胞数量增加。此外，APG通过减少促凋亡的p53和Bax的量以及增加抗凋亡Bcl-2的量在辐射后24h显着抑制了辐射诱导的凋亡。这些结果表明，APG作为癌症患者胃肠道的保护剂可能是治疗性放射的有用辅助剂。

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《Acta Histochemica: Zeitschrift fur Histologische Topochemie》 |2011年第1期|共5页
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Park E; Hwang I; Song JY; Jee Y;
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中图分类人体形态学;
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1. Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice. [J] . Park E, Hwang I, Song JY, Acta Histochemica: Zeitschrift fur Histologische Topochemie . 2011,第1期

机译：人参的酸性多糖可抵抗小鼠全身γ射线对小肠造成的损害。
2. Polysaccharide of Hohenbuehelia serotina as a defense against damage by whole-body gamma irradiation of mice [J] . Xiaoyu Li, Zhenyu Wang, Lu Wang Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides . 2013,第2期

机译：Hohenbuehelia serotina的多糖对小鼠全身γ射线辐射的防御作用
3. Acidic polysaccharide of Panax ginseng regulates the mitochondria/caspase-dependent apoptotic pathway in radiation-induced damage to the jejunum in mice [J] . BingS.J., KimM.J., AhnG., Acta Histochemica: Zeitschrift fur Histologische Topochemie . 2014,第3期

机译：Panax人参酸性多糖调节辐射诱导的小鼠损伤的线粒体/胱天蛋白酶依赖性凋亡途径
4. Enhancement of ginsenoside compounds by far infrared irradiation in ultra fine powdered red ginseng(Panax ginseng C.A. Meyer) [C] . Cheng Wu Jin, Ghimeray Amal Kumar, Won Woo Kim, 2012 12th IEEE International Conference on Nanotechnology. . 2012

机译：在超细粉红色人参中通过远红外辐射增强人参皂甙化合物（Panax ginseng C.A. Meyer）
5. The effect of Korean red ginseng (Panax ginseng C.A. Mayer) on vascular function and influence of derived ginsenosides and polysaccharides. [D] . Jovanovski, Elena. 2007

机译：高丽红参（Panax ginseng C.A. Mayer）对血管功能的影响以及衍生的人参皂甙和多糖的影响。
6. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury [O] . Juliann G. Kiang, Joan T. Smith, Marsha N. Anderson, 2011

机译：出血增强了全身γ射线对合并损伤的肠道损伤后细胞因子，补体成分3和caspase-3的表达，并调节microRNA。
7. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury. [O] . Juliann G Kiang, Joan T Smith, Marsha N Anderson, 2017

机译：出血增强细胞因子，补体成分3和半胱天冬酶-3，并在组合损伤中调节全身γ射线照射后与肠损伤相关的微小RNa。

Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice.

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