Taking the Tube: From Normal Fallopian Tube Epithelium to Ovarian High-grade Serous Carcinoma

ALICIA A. TONE

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Taking the Tube: From Normal Fallopian Tube Epithelium to Ovarian High-grade Serous Carcinoma

机译：采取管：从正常输卵管上皮到卵巢高档浆液癌

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Detailed pathologic studies over the past decade suggest a distal fallopian tube origin for the majority of "ovarian" high-grade serous carcinomas (HGSC). This review will summarize molecular alterations observed in tubal precursors for HGSC, namely p53 signatures and serous tubal intraepithelial carcinomas, and in nonmalignant fallopian tube epithelial cells obtained from women at increased genetic risk for HGSC. Recent experiments investigating the impact of follicular fluid exposure and retrograde menstruation on tumor development in the fallopian tube will also be discussed. These data will be reconciled with traditional ovarian cancer risk factors related to reproductive history.

机译：过去十年的详细病理学研究表明了大多数“卵巢”高级浆液癌（HGSC）的远端输卵管起源。本综述将总结在HGSC的输卵管前体中观察到的分子改变，即P53签名和浆液管上皮内癌，并且在妇女增加了HGSC的遗传风险增加的非开始输卵管上皮细胞。还讨论了研究滤泡液暴露和逆行月经对输卵管中肿瘤发育的影响的最新实验。这些数据将与传统卵巢癌危险因素与生殖历史相关联。

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来源
《Clinical Obstetrics and Gynecology》 |2017年第4期|共14页
作者
ALICIA A. TONE;
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作者单位

Division of Gynecologic Oncology Princess Margaret Cancer Center Toronto Ontario Canada;

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原文格式 PDF
正文语种 eng
中图分类妇产科学;
关键词
fallopian tube; high-grade serous carcinoma; precursor lesions; molecular alterations; follicular fluid; retrograde menstruation;

机译：输卵管;高级浆液癌;前体病变;分子改变;滤泡液;逆行月经;

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专利

1. Taking the Tube: From Normal Fallopian Tube Epithelium to Ovarian High-grade Serous Carcinoma [J] . ALICIA A. TONE Clinical Obstetrics and Gynecology . 2017,第4期

机译：采取管：从正常输卵管上皮到卵巢高档浆液癌
2. Outcomes of Incidental Fallopian Tube High-Grade Serous Carcinoma and Serous Tubal Intraepithelial Carcinoma in Women at Low Risk of Hereditary Breast and Ovarian Cancer [J] . Chay Wen Yee, McCluggage W. Glenn, Lee Cheng-Han, International journal of gynecological cancer: official journal of the International Gynecological Cancer Society . 2016,第3期

机译：遗传性乳腺癌和卵巢癌风险低的女性中偶然输卵管高级别浆液性癌和浆液性输卵管上皮内癌的结果
3. Outcomes of Incidental Fallopian Tube High-Grade Serous Carcinoma and Serous Tubal Intraepithelial Carcinoma in Women at Low Risk of Hereditary Breast and Ovarian Cancer [J] . Chay Wen Yee, McCluggage W. Glenn, Lee Cheng-Han, International journal of gynecological cancer: official journal of the International Gynecological Cancer Society . 2016,第3期

机译：遗传性乳腺癌和卵巢癌的偶然静脉管高级浆液癌和静脉管中性癌细胞癌的结果
4. Global proteomic analysis of ovarian high-grade serous carcinomas using SWATH-MS for targeted verification of proteome changes associated with genomic alterations [C] . Stefani N. Thomas, Jing Chen, Paul Aiyetan, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：卵巢高级浆液癌的全局蛋白质组学分析使用SWATH-MS进行靶向验证与基因组改变相关的蛋白质组变化
5. Inhibitory Functions of SUSD2 in the Progression of High-Grade Serous Ovarian Carcinoma. [D] . Sheets, Jordan N. 2017

机译：SUSD2在高级浆液性卵巢癌进展中的抑制作用。
6. Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium [O] . Laura H. Rodgers, Eoghainín Ó hAinmhire, Alexandria N. Young, 2016

机译：尽管输卵管和卵巢表面上皮细胞具有独特的作用方式但高级浆液性卵巢癌中PAX8的丢失会降低细胞存活率
7. Serous Tubal Carcinogenesis: The Recent Concept of Origin of Ovarian, Primary Peritoneal and Fallopian Tube High-Grade Serous Carcinoma [O] . Tushar Kar, Asaranti Kar, Ipsita Dhal, 2017

机译：浆液输卵管致癌：最近卵巢，原发性腹膜和输卵管高级浆液癌的起源概念
8. Development of a Conditional Transgenic Mouse Model to Test the Fallopian Tube Origin of Serous Ovarian Cancer [R] . Shepherd, T. 2009

机译：开发一种条件转基因小鼠模型来检测浆液性卵巢癌的输卵管起源

Taking the Tube: From Normal Fallopian Tube Epithelium to Ovarian High-grade Serous Carcinoma

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